N-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-benzyl}-2-(7-dimethylamino-2-oxo-2H-chromen-4-yl)-N-methyl-acetamide

Base Information

Chemical Name:N-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-benzyl}-2-(7-dimethylamino-2-oxo-2H-chromen-4-yl)-N-methyl-acetamide
CAS No.:864685-61-0
Molecular Formula:C₄₇H₄₈N₈O₃
Molecular Weight:772.95
Hs Code.:

<i>N</i>-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-benzyl}-2-(7-dimethylamino-2-oxo-2<i>H</i>-chromen-4-yl)-<i>N</i>-methyl-acetamide

Synonyms:N-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-benzyl}-2-(7-dimethylamino-2-oxo-2H-chromen-4-yl)-N-methyl-acetamide

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Chemical Property of N-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-benzyl}-2-(7-dimethylamino-2-oxo-2H-chromen-4-yl)-N-methyl-acetamide

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Technology Process of N-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-benzyl}-2-(7-dimethylamino-2-oxo-2H-chromen-4-yl)-N-methyl-acetamide

There total 5 articles about N-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-benzyl}-2-(7-dimethylamino-2-oxo-2H-chromen-4-yl)-N-methyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 864685-59-6
3,5-bis(2,2'-dipicolylaminomethyl)benzylmethylamine

: 80883-54-1
7-(dimethylamino)coumarin-4-acetic acid

: 864685-61-0
N-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-benzyl}-2-(7-dimethylamino-2-oxo-2H-chromen-4-yl)-N-methyl-acetamide

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/ja052838y

Reference yield:

: {3-[(bis-pyridin-2-ylmethyl-amino)-methyl]-5-bromomethyl-benzyl}-bis-pyridin-2-ylmethyl-amine

: 864685-61-0
N-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-benzyl}-2-(7-dimethylamino-2-oxo-2H-chromen-4-yl)-N-methyl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 870 mg / methanol; H₂O / 2 h / 20 °C

2: 59 percent / 1-hydroxybenzotriazole hydrate; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; N,N'-diisopropylethylamine / dimethylformamide / 24 h / 20 °C

With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ja052838y

Reference yield:

: 864685-58-5
3,5-bis(2,2'-dipicolylaminomethyl)benzyl alcohol

: 864685-61-0
N-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-benzyl}-2-(7-dimethylamino-2-oxo-2H-chromen-4-yl)-N-methyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: aq. HBr / 3 h / Heating

2: 870 mg / methanol; H₂O / 2 h / 20 °C

3: 59 percent / 1-hydroxybenzotriazole hydrate; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; N,N'-diisopropylethylamine / dimethylformamide / 24 h / 20 °C

With hydrogen bromide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ja052838y