(S)-1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}-indazole-5-carboxylic acid

Base Information

Chemical Name:(S)-1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}-indazole-5-carboxylic acid
CAS No.:1643461-25-9
Molecular Formula:C₃₂H₃₇N₃O₅
Molecular Weight:543.663
Hs Code.:

Synonyms:(S)-1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}-indazole-5-carboxylic acid

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Chemical Property of (S)-1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}-indazole-5-carboxylic acid

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Technology Process of (S)-1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}-indazole-5-carboxylic acid

There total 8 articles about (S)-1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}-indazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1643461-43-1
(S)-allyl 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]-propyl}indazole-5-carboxylate

: 1643461-25-9
(S)-1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}-indazole-5-carboxylic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1039/c4ob00535j

Reference yield:

: 61700-61-6
1H-indazole-5-carboxylic acid

: 1643461-25-9
(S)-1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}-indazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 3 h / 70 °C

3.1: hydrogenchloride / tetrahydrofuran / 3 h / 70 °C

4.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

5.2: 3 h / 80 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid / tetrahydrofuran / 6 h / 20 °C

With hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c4ob00535j

Reference yield:

: 1643461-26-0
allyl indazole-5-carboxylate

: 1643461-25-9
(S)-1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}-indazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 3 h / 70 °C

2.1: hydrogenchloride / tetrahydrofuran / 3 h / 70 °C

3.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

4.2: 3 h / 80 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid / tetrahydrofuran / 6 h / 20 °C

With hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c4ob00535j