N-[2-(3,4,6,7,12,12a-Hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-terephthalamic acid ethyl ester

Base Information

Chemical Name:N-[2-(3,4,6,7,12,12a-Hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-terephthalamic acid ethyl ester
CAS No.:72593-26-1
Molecular Formula:C₂₆H₃₀N₄O₃
Molecular Weight:446.549
Hs Code.:

Synonyms:N-[2-(3,4,6,7,12,12a-Hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-terephthalamic acid ethyl ester

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Chemical Property of N-[2-(3,4,6,7,12,12a-Hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-terephthalamic acid ethyl ester

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Technology Process of N-[2-(3,4,6,7,12,12a-Hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-terephthalamic acid ethyl ester

There total 3 articles about N-[2-(3,4,6,7,12,12a-Hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-terephthalamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.6%

: 91119-31-2
2-β-Aminoethyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole

: 27111-45-1
ethyl 4-(chlorocarbonyl)benzoate

: 72593-26-1
N-[2-(3,4,6,7,12,12a-Hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-terephthalamic acid ethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; 1) 1h, 30 deg C, 2) 5h, reflux;

Reference yield:

: 91119-30-1
2-Cyanomethyl 1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indol

: 72593-26-1
N-[2-(3,4,6,7,12,12a-Hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-terephthalamic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78.6 percent / LAH / tetrahydrofuran / 10 h / Heating

2: 66.6 percent / Et₃N / tetrahydrofuran / 1) 1h, 30 deg C, 2) 5h, reflux

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran;

Reference yield:

: 55344-28-0
1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole

: 72593-26-1
N-[2-(3,4,6,7,12,12a-Hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-terephthalamic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 76.5 percent / Na₂CO₃ / dimethylformamide / 24 h / 30 °C

2: 78.6 percent / LAH / tetrahydrofuran / 10 h / Heating

3: 66.6 percent / Et₃N / tetrahydrofuran / 1) 1h, 30 deg C, 2) 5h, reflux

With lithium aluminium tetrahydride; sodium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;