(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol acetate

Base Information

Chemical Name:(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol acetate
CAS No.:127633-62-9
Molecular Formula:C₁₉H₃₁BrO₃Si
Molecular Weight:415.443
Hs Code.:

Synonyms:(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol acetate

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Technology Process of (S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol acetate

There total 7 articles about (S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 127633-44-7
(R)-(+)-2-<2-(4-Bromophenyl)ethyl>-1,3-propanediol monoacetate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 127633-62-9
(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol acetate

Guidance literature:: With 1H-imidazole; In dichloromethane;
DOI:10.1016/S0040-4039(01)93875-4

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: (RS)-2-<2-(4-Bromophenyl)ethyl>-1,3-propanediol monoacetate

: 127633-62-9
(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol acetate

: (R)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol acetate

Guidance literature:: With 1H-imidazole; In dichloromethane; at 17 - 20 ℃; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00102a031

Reference yield:

: 4654-39-1
4-bromophenethanol

: 127633-62-9
(S)-(-)-4-Bromo-β-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzenebutanol acetate

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N

2: 90 percent / NaH

3: 75 percent / LiAlH₄ / diethyl ether

4: 90 percent / with porcine pancreatic lipase (PPL, Sigma type II, no. 3126)

5: 88 percent / imidazole / CH₂Cl₂

With 1H-imidazole; lithium aluminium tetrahydride; sodium hydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(01)93875-4