C₁₁H₁₁FO₃

Base Information

• Chemical Name: C₁₁H₁₁FO₃
• CAS No.: 1416263-30-3
• Molecular Formula: C₁₁H₁₁FO₃
• Molecular Weight: 210.205
• Mol file: 1416263-30-3.mol

Synonyms:C₁₁H₁₁FO₃

Chemical Property of C₁₁H₁₁FO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₁H₁₁FO₃

There total 3 articles about C₁₁H₁₁FO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2,3-dihydro-2-(4-fluorophenyl)-4H-pyran-4-one → C11H11FO3 (1416263-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: cerium(III) chloride heptahydrate; sodium tetrahydroborate / dichloromethane; methanol / 0.5 h / -20 °C

2: dihydrogen peroxide; molybdenum(VI) oxide / acetonitrile / 24 h

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; dihydrogen peroxide; molybdenum(VI) oxide; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/jo400807c

Reference yield:

4-fluorobenzaldehyde (459-57-4) → C11H11FO3 (1416263-30-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: [(R,R)-salen-Cr]BF₄ / tert-butyl methyl ether / 24 h / -30 °C / Molecular sieve

1.2: 5 h / 20 °C

2.1: cerium(III) chloride heptahydrate; sodium tetrahydroborate / dichloromethane; methanol / 0.5 h / -20 °C

3.1: dihydrogen peroxide; molybdenum(VI) oxide / acetonitrile / 24 h

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; [(R,R)-salen-Cr]BF₄; dihydrogen peroxide; molybdenum(VI) oxide; In methanol; dichloromethane; tert-butyl methyl ether; acetonitrile;

DOI:10.1021/jo400807c

Reference yield:

(2R)-2-(4-fluorophenyl)-3,4-dihydro-2H-pyran-4-ol (1416263-27-8) → C11H11FO3 (1416263-30-3)

Guidance literature:

With dihydrogen peroxide; molybdenum(VI) oxide; In acetonitrile; for 24h;

DOI:10.1021/jo400807c

upstream raw materials:

4-fluorobenzaldehyde

(2R)-2-(4-fluorophenyl)-3,4-dihydro-2H-pyran-4-ol

Downstream raw materials:

(1'R,6R)-3-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-5,6-dihydro-2H-pyran-2-one

(1'S,3R,6R)-3-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-tetrahydro-2H-pyran-2-one

C₃₁H₂₉F₂NO₃

(1'S,3R,6S)-3-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-tetrahydro-2H-pyran-2-one