(1'R,6R)-3-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-5,6-dihydro-2H-pyran-2-one

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Chemical Name:(1'R,6R)-3-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-5,6-dihydro-2H-pyran-2-one
CAS No.:1416263-33-6
Molecular Formula:C₃₁H₂₅F₂NO₃
Molecular Weight:497.541
Hs Code.:

Synonyms:(1'R,6R)-3-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-5,6-dihydro-2H-pyran-2-one

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Chemical Property of (1'R,6R)-3-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-5,6-dihydro-2H-pyran-2-one

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Technology Process of (1'R,6R)-3-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-5,6-dihydro-2H-pyran-2-one

There total 13 articles about (1'R,6R)-3-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-5,6-dihydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1416263-32-5
(3S,4S,6R,1'S)-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-4-hydroxy-tetrahydro-2H-pyran-2-one

: 1416263-33-6
(1'R,6R)-3-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-5,6-dihydro-2H-pyran-2-one

Guidance literature:: (3S,4S,6R,1'S)-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-4-hydroxy-tetrahydro-2H-pyran-2-one; With 1H-imidazole; chloro-trimethyl-silane; In dichloromethane; at 20 ℃; for 0.5h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1021/jo400807c

Reference yield:

: 1416263-27-8
(2R)-2-(4-fluorophenyl)-3,4-dihydro-2H-pyran-4-ol

: 1416263-33-6
(1'R,6R)-3-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-5,6-dihydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: dihydrogen peroxide; molybdenum(VI) oxide / acetonitrile / 24 h

2.1: pyridine; acetic anhydride / dichloromethane / 2 h / 20 °C

3.1: scandium tris(trifluoromethanesulfonate) / toluene / 72 h / 30 °C / Molecular sieve

4.1: potassium iodide; chloro-trimethyl-silane / acetonitrile / 0.58 h / 20 °C

5.1: chloro-trimethyl-silane; 1H-imidazole / dichloromethane / 0.5 h / 20 °C

5.2: 0.25 h / 20 °C

With pyridine; 1H-imidazole; chloro-trimethyl-silane; dihydrogen peroxide; acetic anhydride; potassium iodide; molybdenum(VI) oxide; scandium tris(trifluoromethanesulfonate); In dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo400807c

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1416263-33-6
(1'R,6R)-3-[(4-benzyloxyphenyl)-(4-fluorophenylamino)-methyl]-6-(4-fluorophenyl)-5,6-dihydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc; ammonium chloride / water / 0.25 h / 60 °C

2.1: methanesulfonic acid / acetone / 2 h / 20 °C

3.1: toluene / 72 h / Reflux

4.1: potassium iodide; chloro-trimethyl-silane / acetonitrile / 0.58 h / 20 °C

5.1: chloro-trimethyl-silane; 1H-imidazole / dichloromethane / 0.5 h / 20 °C

5.2: 0.25 h / 20 °C

With 1H-imidazole; chloro-trimethyl-silane; methanesulfonic acid; ammonium chloride; potassium iodide; zinc; In dichloromethane; water; acetone; toluene; acetonitrile;
DOI:10.1021/jo400807c