(R)-1-[4-(2-methylbenzoylamino)benzoyl]-5-(N-methyl-tert-butoxycarbonylamino)-2,3,4,5-tetrahydro-1H-1-benzazepine

Base Information

Chemical Name:(R)-1-[4-(2-methylbenzoylamino)benzoyl]-5-(N-methyl-tert-butoxycarbonylamino)-2,3,4,5-tetrahydro-1H-1-benzazepine
CAS No.:294196-64-8
Molecular Formula:C₃₁H₃₅N₃O₄
Molecular Weight:513.637
Hs Code.:

Synonyms:(R)-1-[4-(2-methylbenzoylamino)benzoyl]-5-(N-methyl-tert-butoxycarbonylamino)-2,3,4,5-tetrahydro-1H-1-benzazepine

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Chemical Property of (R)-1-[4-(2-methylbenzoylamino)benzoyl]-5-(N-methyl-tert-butoxycarbonylamino)-2,3,4,5-tetrahydro-1H-1-benzazepine

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Technology Process of (R)-1-[4-(2-methylbenzoylamino)benzoyl]-5-(N-methyl-tert-butoxycarbonylamino)-2,3,4,5-tetrahydro-1H-1-benzazepine

There total 6 articles about (R)-1-[4-(2-methylbenzoylamino)benzoyl]-5-(N-methyl-tert-butoxycarbonylamino)-2,3,4,5-tetrahydro-1H-1-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 168080-31-7
4-(2-methylbenzoylamino)benzoic acid chloride

: 294196-58-0
(R)-5-(N-methyl-tert-butoxycarbonylamino)-2,3,4,5-tetrahydro-1H-1-benzazepine

: 294196-64-8
(R)-1-[4-(2-methylbenzoylamino)benzoyl]-5-(N-methyl-tert-butoxycarbonylamino)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: With pyridine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 10 ℃; for 2h;
DOI:10.1016/S0040-4020(00)00388-4

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 294196-64-8
(R)-1-[4-(2-methylbenzoylamino)benzoyl]-5-(N-methyl-tert-butoxycarbonylamino)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

2: 94 percent / sodium hydride / dimethylformamide; various solvent(s) / 1.5 h / 20 °C

3: 83 percent / magnesium / methanol / 4 h / Heating

4: pyridine / CH₂Cl₂; dimethylformamide / 2 h / 0 - 10 °C

With pyridine; sodium hydride; magnesium; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: Methylation / 3: Reduction / 4: Acylation;
DOI:10.1016/S0040-4020(00)00388-4

Reference yield:

: 108166-22-9
4-[(2-Methylbenzoyl)amino]benzoic acid

: 294196-64-8
(R)-1-[4-(2-methylbenzoylamino)benzoyl]-5-(N-methyl-tert-butoxycarbonylamino)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dimethylformamide; CH₂Cl₂ / 1 h / Heating

2: pyridine / CH₂Cl₂; dimethylformamide / 2 h / 0 - 10 °C

With pyridine; thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; 1: Chlorination / 2: Acylation;
DOI:10.1016/S0040-4020(00)00388-4