108166-22-9

Usage

Uses

Used in Scientific Research:
4-[(2-Methylbenzoyl)amino]benzoic acid is used as a research chemical for various scientific applications. Its unique structure, which includes both benzoyl and amino groups, makes it a valuable compound for studying chemical reactions and interactions within different research fields.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 4-[(2-methylbenzoyl)amino]benzoic acid is used as a key intermediate in the synthesis of various drug molecules. Its versatile structure allows for the development of new compounds with potential therapeutic applications, contributing to the advancement of medicine.
Used in Chemical Synthesis:
4-[(2-Methylbenzoyl)amino]benzoic acid is employed as a building block in the synthesis of complex organic molecules. Its presence in the phenylbenzamides and anilides family makes it a valuable component in the creation of new chemical entities with diverse properties and potential applications.
Used in Material Science:
In the field of material science, 4-[(2-methylbenzoyl)amino]benzoic acid is used as a component in the development of new materials with specific properties. Its incorporation into various chemical structures can lead to the creation of materials with improved characteristics, such as enhanced stability or increased reactivity.

Upstream product

• 933-88-0 ortho-toluoyl chloride 
• 94-09-7 p-aminoethylbenzoate 
• 118-90-1 ortho-methylbenzoic acid 
• 200278-95-1 methyl 4-(2-methylbenzamido)benzoate 
• 619-45-4 4-methoxycarbonyl aniline 

Downstream Products

• 168080-31-7 4-(2-methylbenzoylamino)benzoic acid chloride 
• 168078-48-6 2-methyl-N-[4-(pyrrolo[1,2-a]quinoxalin-5(4H)-ylcarbonyl)-phenyl]benzamide 
• 169878-67-5 N-[4-[(6,11-Dihydro-5H-dibenz[b,e]azepin-5-yl)-carbonyl]phenyl]-2-methylbenzamide 
• 157239-63-9 (R)-5-methylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 157239-62-8 (S)-5-methylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 

Relevant academic research and scientific papers

Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: Characteristics of broad-spectrum protein binding and its effects on anti-tumor activity

On the basis of the comparison of the structure of the Bim BH3: Bcl-x L complex and that of the ABT-737: Bcl-xL complex, a series of class A compounds were designed. These compounds had the basic skeleton of ABT-737 and the h2 residues of Bim BH3. These residues had shown themselves to be relevant to Bim BH3's broad-spectrum binding properties in saturation mutagenesis assays. Unlike ABT-737, which is a selective inhibitor of anti-apoptotic members of the Bcl-2 protein family, the class A compounds showed broad-spectrum binding activity to target proteins similar to those of Bim BH3 peptide. Then class B compounds were synthesized by modifying the structure of the most effective class A compound, A-4. Most of these class B compounds showed better binding affinity to the target proteins than the class A compounds had. They also showed themselves more effective than ABT-737 at inhibiting growth in multiple tumor cell lines known to express Bcl-x L, Bcl-2, and Mcl-1 proteins at high levels. Compounds B-11 and B-12 had the strongest anti-tumor activity of any compounds we produced. This study suggests that it is feasible to design small-molecule inhibitors based on the structure of Bim BH3, which shows broad-spectrum binding to Bcl-xL, Bcl-2, and Mcl-1 proteins. Our results also suggest that the broad-spectrum properties of small-molecule inhibitors binding to target proteins play a critical role in inhibiting the growth of many tumor cells. Finally, our study provides a series of lead compounds that merit further research into anti-cancer therapeutics.

Novel and efficient copper-catalysed synthesis of nitrogen-linked medium-ring biaryls

Herein, a new copper-catalysed strategy for the synthesis of rare nitrogen-linked seven-, eight- and nine-membered biaryl ring systems is described. It is proposed that the reaction proceeds through a highly activated intramolecularly co-ordinated copper

Structure-activity study of novel tricyclic benzazepine arginine vasopressin antagonists

Novel tricyclic benzazepine derivatives were synthesized as arginine vasopressin (AVP) antagonists. Several tricyclic compounds showed potent antagonistic activity in rat AVP receptors V1a and V2. Derivatives containing pyrrolo-tricy