Technology Process of 3-(3,4-dimethoxybenzyl)-7-fluoro-6-hydroxy-1-(tetrahydro-2H-pyran-4-yl)quinazoline-2,4(1H,3H)-dione
There total 7 articles about 3-(3,4-dimethoxybenzyl)-7-fluoro-6-hydroxy-1-(tetrahydro-2H-pyran-4-yl)quinazoline-2,4(1H,3H)-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonium formate;
palladium 10% on activated carbon;
In
ethanol;
at 60 ℃;
for 0.0833333h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tetrahydrofuran / 0.17 h / 20 °C
1.2: 1 h / 20 °C
2.1: ammonium chloride; iron / isopropyl alcohol; water; tetrahydrofuran / 6 h / 90 °C
3.1: sodium sulfate / acetic acid / 20 °C
3.2: 3 h / 20 °C
4.1: potassium hydroxide; water / isopropyl alcohol / 0.33 h / 130 °C / Microwave irradiation
5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / 80 °C / Microwave irradiation
6.2: 1 h / 20 °C
7.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.08 h / 60 °C / Microwave irradiation
With
water; ammonium formate; iron; ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium sulfate; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: ammonium chloride; iron / isopropyl alcohol; water; tetrahydrofuran / 6 h / 90 °C
2.1: sodium sulfate / acetic acid / 20 °C
2.2: 3 h / 20 °C
3.1: potassium hydroxide; water / isopropyl alcohol / 0.33 h / 130 °C / Microwave irradiation
4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / 80 °C / Microwave irradiation
5.2: 1 h / 20 °C
6.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.08 h / 60 °C / Microwave irradiation
With
water; ammonium formate; iron; ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium sulfate; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;