Ethyl 4,5-Difluoro-2-nitrobenzoate

Base Information

• Chemical Name: Ethyl 4,5-Difluoro-2-nitrobenzoate
• CAS No.: 1214387-06-0
• Molecular Formula: C9H7F2NO4
• Molecular Weight: 231.156
• Hs Code.: 2916399090
• Mol file: 1214387-06-0.mol

Synonyms:ethyl 4,5-difluoro-2-nitrobenzoate;4,5-difluoro-2-nitrobenzoic acid ethyl ester;2-Thiophenecarboxylic acid,4,5-dibromo-,ethyl ester;ethyl 4,5-dibromo-2-thiophenecarboxylate;4,5-dibromo-thiophene-2-carboxylic acid ethyl ester;4,5-Dibromthiophen-2-carbonsaeureaethylester;

Chemical Property of Ethyl 4,5-Difluoro-2-nitrobenzoate

Chemical Property:

• Boiling Point: 302.3±42.0 °C(Predicted)
• PSA: 72.12000
• Density: 1.408±0.06 g/cm3(Predicted)
• LogP: 2.57290
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4,5-Difluoro-2-nitrobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4,5-Difluoro-2-nitrobenzoate

There total 1 articles about Ethyl 4,5-Difluoro-2-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + 4,5-difluoro-2-nitrobenzoic acid (20372-63-8) → 4,5-difluoro-2-nitrobenzoic acid ethyl ester (1214387-06-0)

Guidance literature:

4,5-difluoro-2-nitrobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 2h;

ethanol; In dichloromethane; at 0 - 20 ℃; for 5h;

Reference yield:

4,5-difluoro-2-nitrobenzoic acid ethyl ester (1214387-06-0) + trimethyltin(IV)chloride (1066-45-1) → 4,5-difluoro-3-(trimethylstannyl)-2-nitrobenzoic acid ethyl ester

Guidance literature:

With LiBSBA; In tetrahydrofuran; hexane; at -78 - -74 ℃; for 0.5h;

Reference yield:

4,5-difluoro-2-nitrobenzoic acid ethyl ester (1214387-06-0) + benzyl alcohol (100-51-6,185532-71-2) → ethyl 5-(benzyloxy)-4-fluoro-2-nitrobenzoate (1251702-39-2)

Guidance literature:

benzyl alcohol; In tetrahydrofuran; at 20 ℃; for 0.166667h;

4,5-difluoro-2-nitrobenzoic acid ethyl ester; With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;

upstream raw materials:

ethanol

4,5-difluoro-2-nitrobenzoic acid

Downstream raw materials:

ethyl 5-(benzyloxy)-4-fluoro-2-nitrobenzoate

6-(2,2-difluoroethoxy)-3-(3,4-dimethoxybenzyl)-7-fluoro-1-(tetrahydro-2H-pyran-4-yl)quinazoline-2,4(1H,3H)-dione

ethyl 2-amino-5-(benzyloxy)-4-fluorobenzoate

ethyl 5-(benzyloxy)-4-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzoate