(S)-N-((S)-1-( 2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluorophenyl)-5-oxomorpholine-3-carboxamide

Base Information

Chemical Name:(S)-N-((S)-1-( 2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluorophenyl)-5-oxomorpholine-3-carboxamide
CAS No.:1448348-25-1
Molecular Formula:C₂₃H₂₁ClF₃N₃O₄
Molecular Weight:495.886
Hs Code.:

Synonyms:(S)-N-((S)-1-( 2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluorophenyl)-5-oxomorpholine-3-carboxamide

Suppliers and Price of (S)-N-((S)-1-( 2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluorophenyl)-5-oxomorpholine-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-((S)-1-( 2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluorophenyl)-5-oxomorpholine-3-carboxamide

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of (S)-N-((S)-1-( 2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluorophenyl)-5-oxomorpholine-3-carboxamide

There total 6 articles about (S)-N-((S)-1-( 2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluorophenyl)-5-oxomorpholine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 372-19-0
meta-fluoroaniline

: 1355328-31-2
1,1-difluoro-3-isocyanocyclobutane

: 1448348-24-0
(S)-5-oxomorpholine-3-carboxylic acid

: 587-04-2
m-Chlorobenzaldehyde

: 1448348-25-1
(S)-N-((S)-1-( 2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluorophenyl)-5-oxomorpholine-3-carboxamide

Guidance literature:

Reference yield:

: 1029720-19-1
tert-butyl (3,3-difluorocyclobutyl)carbamate

: 1448348-25-1
(S)-N-((S)-1-( 2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluorophenyl)-5-oxomorpholine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: Petroleum ether; ethyl acetate; methanol; water

2: triphenylphosphine; triethanolamine / tetrachloromethane; diethyl ether

With triethanolamine; triphenylphosphine; In methanol; tetrachloromethane; diethyl ether; water; ethyl acetate; Petroleum ether;

Reference yield:

: 154748-49-9
3-(tert-butyloxycarbonylamino)cyclobutan-1-one

: 1448348-25-1
(S)-N-((S)-1-( 2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluorophenyl)-5-oxomorpholine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: diethylamino-sulfur trifluoride / Petroleum ether; ethyl acetate

2: Petroleum ether; ethyl acetate; methanol; water

3: triphenylphosphine; triethanolamine / tetrachloromethane; diethyl ether

With triethanolamine; diethylamino-sulfur trifluoride; triphenylphosphine; In methanol; tetrachloromethane; diethyl ether; water; ethyl acetate; Petroleum ether;