(R)-4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoic acid

Base Information

Chemical Name:(R)-4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoic acid
CAS No.:1257443-42-7
Molecular Formula:C₁₆H₂₀BrNO₅
Molecular Weight:386.243
Hs Code.:

Synonyms:(R)-4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoic acid

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Chemical Property of (R)-4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoic acid

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Technology Process of (R)-4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoic acid

There total 5 articles about (R)-4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-30-5
succinic acid anhydride

: 1257446-30-2
(R)-ethyl 3-amino-4-(4-bromophenyl)butanoate hydrochloride

: 1257443-42-7
(R)-4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoic acid

Guidance literature:: succinic acid anhydride; (R)-ethyl 3-amino-4-(4-bromophenyl)butanoate hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 4h;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 108-30-5
succinic acid anhydride

: (R)-3-amino-4-bromophenyl-4-yl-butyric acid ethyl ester hydrochloride

: 1257443-42-7
(R)-4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoic acid

Guidance literature:: With DIPEA; In dichloromethane;

Reference yield:

: 331763-75-8
(R)-4-(4-bromophenyl)-3-((tert-butoxycarbonyl)amino)butanoic acid

: 1257443-42-7
(R)-4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 71 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h

With hydrogenchloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;