5H-indolo[2,1-a][2]benzazepine-10-carboxamide, 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-6,7-dihydro-3-methoxy-6-[3-(4-morpholinylcarbonyl)-2-pyridinyl]-

Base Information

Chemical Name:5H-indolo[2,1-a][2]benzazepine-10-carboxamide, 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-6,7-dihydro-3-methoxy-6-[3-(4-morpholinylcarbonyl)-2-pyridinyl]-
CAS No.:1112187-62-8
Molecular Formula:C₃₇H₄₃N₅O₆S
Molecular Weight:685.844
Hs Code.:

5H-indolo[2,1-a][2]benzazepine-10-carboxamide, 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-6,7-dihydro-3-methoxy-6-[3-(4-morpholinylcarbonyl)-2-pyridinyl]-

Synonyms:5H-indolo[2,1-a][2]benzazepine-10-carboxamide, 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-6,7-dihydro-3-methoxy-6-[3-(4-morpholinylcarbonyl)-2-pyridinyl]-

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Chemical Property of 5H-indolo[2,1-a][2]benzazepine-10-carboxamide, 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-6,7-dihydro-3-methoxy-6-[3-(4-morpholinylcarbonyl)-2-pyridinyl]-

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Technology Process of 5H-indolo[2,1-a][2]benzazepine-10-carboxamide, 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-6,7-dihydro-3-methoxy-6-[3-(4-morpholinylcarbonyl)-2-pyridinyl]-

There total 8 articles about 5H-indolo[2,1-a][2]benzazepine-10-carboxamide, 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-6,7-dihydro-3-methoxy-6-[3-(4-morpholinylcarbonyl)-2-pyridinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1112187-12-8
7H-indolo[2,1-a][2]benzazepine-10-carboxamide, 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-[3-(4-morpholinylcarbonyl)-2-pyridinyl]-

: 1112187-62-8
5H-indolo[2,1-a][2]benzazepine-10-carboxamide, 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-6,7-dihydro-3-methoxy-6-[3-(4-morpholinylcarbonyl)-2-pyridinyl]-

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In isopropyl alcohol; at 22 ℃; for 6h; under 760.051 Torr;

Reference yield:

: 958002-18-1
1H-indole-6-carboxylic acid, 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-, 1,1-dimethylethyl ester

: 1112187-62-8
5H-indolo[2,1-a][2]benzazepine-10-carboxamide, 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-6,7-dihydro-3-methoxy-6-[3-(4-morpholinylcarbonyl)-2-pyridinyl]-

Guidance literature:: Multi-step reaction with 7 steps

1: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine / 1,4-dioxane / 0.25 h / 120 °C / Microwave irradiation

2: 2,2'-azobis(isobutyronitrile); triethylamine / benzene / 13.33 h / Heating / reflux

3: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 160 °C / Microwave irradiation

4: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 22 °C

5: tetrahydrofuran / 2.5 h / 22 °C / Heating / reflux

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 19 h / 20 - 22 °C / Heating / reflux

7: hydrogen / palladium 10% on activated carbon / isopropyl alcohol / 6 h / 22 °C / 760.05 Torr

With 2,2'-azobis(isobutyronitrile); hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1,2-dichloro-ethane; isopropyl alcohol; benzene;

Reference yield:

: 945627-35-0
7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-3-methoxy-6-(phenylsulfonyl)-, 1,1-dimethylethyl ester

: 1112187-62-8
5H-indolo[2,1-a][2]benzazepine-10-carboxamide, 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-6,7-dihydro-3-methoxy-6-[3-(4-morpholinylcarbonyl)-2-pyridinyl]-

Guidance literature:: Multi-step reaction with 6 steps

1: 2,2'-azobis(isobutyronitrile); triethylamine / benzene / 13.33 h / Heating / reflux

2: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 160 °C / Microwave irradiation

3: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 22 °C

4: tetrahydrofuran / 2.5 h / 22 °C / Heating / reflux

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 19 h / 20 - 22 °C / Heating / reflux

6: hydrogen / palladium 10% on activated carbon / isopropyl alcohol / 6 h / 22 °C / 760.05 Torr

With 2,2'-azobis(isobutyronitrile); hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,2-dichloro-ethane; isopropyl alcohol; benzene;