tert-butyl 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-1H-indole-6-carboxylate

Base Information

Chemical Name:tert-butyl 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-1H-indole-6-carboxylate
CAS No.:958002-18-1
Molecular Formula:C27H31NO4
Molecular Weight:433.547
Hs Code.:
Mol file:958002-18-1.mol

Synonyms:3-cyclohexyl-2-(2-formyl-4-methoxypenyl)-1H-indole-6-carboxic acid 1,1-dimethylethyl ester;t-butyl 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-1H-indole-6-carboxylate;tert-butyl 3-cyclohexyl-2-(2-formyl-4-methoxy-phenyl)-1H-indole-6-carboxylate;1H-Indole-6-carboxylic acid,3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-,1,1-dimethylethyl ester;1,1-dimethylethyl 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-1H-indole-6-carboxylate;3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-1H-indole-6-carboxylic acid 1,1-dimethylethyl ester;

Suppliers and Price of tert-butyl 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-1H-indole-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 6 raw suppliers

Chemical Property of tert-butyl 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-1H-indole-6-carboxylate

Chemical Property:

PSA：68.39000
LogP:6.65900

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-1H-indole-6-carboxylate

There total 11 articles about tert-butyl 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 139962-95-1
2-formyl-4-methoxyphenylboronic acid

: 958002-18-1
1H-indole-6-carboxylic acid, 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-, 1,1-dimethylethyl ester

Guidance literature:: 1H-indole-6-carboxylic acid, 2-bromo-3-cyclohexyl-, 1,1-dimethylethyl ester; With sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; for 0.25h;

2-formyl-4-methoxyphenylboronic acid; In ethanol; toluene; at 85 ℃; for 4h;

Reference yield: 74.0%

: 879498-90-5
1H-indole-6-carboxylic acid, 2-bromo-3-cyclohexyl-, 1,1-dimethylethyl ester

: 139962-95-1
2-formyl-4-methoxyphenylboronic acid

: 958002-18-1
1H-indole-6-carboxylic acid, 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-, 1,1-dimethylethyl ester

Guidance literature:: With sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 85 ℃; for 4h;

Reference yield:

: 494799-18-7
methyl 3-cyclohexyl-1H-indole-6-carboxylate

: 958002-18-1
1H-indole-6-carboxylic acid, 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2 - 2.66 h / 0 - 20 °C

2.1: methanol; lithium hydroxide; water / tetrahydrofuran / 2 - 3 h / 90 °C

2.2: 1 h / 0 - 20 °C

3.1: silver carbonate / tetrahydrofuran; dichloromethane / 0 - 20 °C / Molecular sieve

4.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 4.25 h / 85 °C

With methanol; lithium hydroxide; water; sodium carbonate; pyridinium hydrobromide perbromide; silver carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene;