1-[(2-chlorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

Base Information

Chemical Name:1-[(2-chlorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
CAS No.:1430750-66-5
Molecular Formula:C₁₆H₂₀BClN₂O₂
Molecular Weight:318.611
Hs Code.:

Synonyms:1-[(2-chlorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

Suppliers and Price of 1-[(2-chlorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Matrix Scientific
1-(2-Chlorobenzyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole
1g
$ 1073.00

A1 Biochem Labs
1-(2-Chloro-benzyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 95%
2.5 g
$ 900.00

Total 0 raw suppliers

Chemical Property of 1-[(2-chlorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

Chemical Property:

Purity/Quality:: 1-(2-Chlorobenzyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Useful:

Technology Process of 1-[(2-chlorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

There total 3 articles about 1-[(2-chlorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 269410-08-4
pyrazole-4-boronic acid pinacol ester

: 17849-38-6
2-Chlorobenzyl alcohol

: 1430750-66-5
1-[(2-chlorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 0.5h; Reflux;

Reference yield: 30.0%

: 957265-68-8
1-(2-chlorobenzyl)-4-iodo-1H-pyrazole

: 73183-34-3
bis(pinacol)diborane

: 1430750-66-5
1-[(2-chlorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In N,N-dimethyl-formamide; at 80 ℃; for 16h;
DOI:10.1021/jm500073h

Reference yield:

: 611-19-8
1-chloro-2-(chloromethyl)benzene

: 1430750-66-5
1-[(2-chlorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / acetonitrile / 18 h / Reflux

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; caesium carbonate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm500073h