2-[(2-Acetylamino-acetyl)-benzyl-amino]-4-methyl-pentanoic acid (2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethyl)-amide

Base Information

Chemical Name:2-[(2-Acetylamino-acetyl)-benzyl-amino]-4-methyl-pentanoic acid (2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethyl)-amide
CAS No.:460048-65-1
Molecular Formula:C₂₇H₄₂N₄O₅
Molecular Weight:502.654
Hs Code.:

Synonyms:2-[(2-Acetylamino-acetyl)-benzyl-amino]-4-methyl-pentanoic acid (2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethyl)-amide

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Chemical Property of 2-[(2-Acetylamino-acetyl)-benzyl-amino]-4-methyl-pentanoic acid (2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethyl)-amide

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Technology Process of 2-[(2-Acetylamino-acetyl)-benzyl-amino]-4-methyl-pentanoic acid (2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethyl)-amide

There total 7 articles about 2-[(2-Acetylamino-acetyl)-benzyl-amino]-4-methyl-pentanoic acid (2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.4%

: 100-46-9
benzylamine

: 590-86-3
isovaleraldehyde

: 543-24-8
N-acetylglycine

: 460048-61-7
formic acid 1-cyclohexylcarbamoyl-2-isocyano-propyl ester

: 460048-65-1
2-[(2-Acetylamino-acetyl)-benzyl-amino]-4-methyl-pentanoic acid (2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethyl)-amide

Guidance literature:: In methanol; dichloromethane; at 20 ℃; for 48h;
DOI:10.1055/s-2002-31948

Reference yield:

: 51737-90-7
N-Cyclohexyl-2-oxo-acetamide

: 460048-65-1
2-[(2-Acetylamino-acetyl)-benzyl-amino]-4-methyl-pentanoic acid (2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 19.0 g / KF/Al₂O₃ / 48 h / 20 °C

2.1: H₂; HCOOH / 10 percent Pd/C; P-2 Ni / methanol / 12 h / 20 °C / 3040 Torr

2.2: Zn; aq. NH₄Cl / methanol / 12 h / 20 °C

3.1: 1.33 g / imidazole; DCC; HCOOH / Et₃N / 48 h / 20 °C

4.1: POCl₃; Et₃N / CH₂Cl₂ / 0.5 h

5.1: 36.4 percent / methanol; CH₂Cl₂ / 48 h / 20 °C

With 1H-imidazole; aluminum oxide; potassium fluoride; formic acid; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trichlorophosphate; palladium on activated charcoal; triethylamine; In methanol; dichloromethane; 5.1: Ugi reaction;
DOI:10.1055/s-2002-31948

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 460048-65-1
2-[(2-Acetylamino-acetyl)-benzyl-amino]-4-methyl-pentanoic acid (2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 76.7 percent / K₂CO₃ / methanol / 7 h / Heating

2.1: H₅IO₆ / ethanol; diethyl ether / 24 h / 20 °C

3.1: 19.0 g / KF/Al₂O₃ / 48 h / 20 °C

4.1: H₂; HCOOH / 10 percent Pd/C; P-2 Ni / methanol / 12 h / 20 °C / 3040 Torr

4.2: Zn; aq. NH₄Cl / methanol / 12 h / 20 °C

5.1: 1.33 g / imidazole; DCC; HCOOH / Et₃N / 48 h / 20 °C

6.1: POCl₃; Et₃N / CH₂Cl₂ / 0.5 h

7.1: 36.4 percent / methanol; CH₂Cl₂ / 48 h / 20 °C

With 1H-imidazole; aluminum oxide; potassium fluoride; formic acid; hydrogen; potassium carbonate; periodic acid; triethylamine; dicyclohexyl-carbodiimide; trichlorophosphate; palladium on activated charcoal; triethylamine; In methanol; diethyl ether; ethanol; dichloromethane; 7.1: Ugi reaction;
DOI:10.1055/s-2002-31948