4-methyl-N-(pent-4-en-1-yl)-N-(phenylethynyl)benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-(pent-4-en-1-yl)-N-(phenylethynyl)benzenesulfonamide
• CAS No.: 888488-10-6
• Molecular Formula: C₂₀H₂₁NO₂S
• Molecular Weight: 339.458
• Mol file: 888488-10-6.mol

Synonyms:4-methyl-N-(pent-4-en-1-yl)-N-(phenylethynyl)benzenesulfonamide

Chemical Property of 4-methyl-N-(pent-4-en-1-yl)-N-(phenylethynyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-(pent-4-en-1-yl)-N-(phenylethynyl)benzenesulfonamide

There total 15 articles about 4-methyl-N-(pent-4-en-1-yl)-N-(phenylethynyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

iodobenzene (591-50-4) + N-(2,2-dichlorovinyl)-N-(pent-4-enyl)-p-toluenesulfonamide (406179-99-5) → 4-methyl-N-(pent-4-en-1-yl)-N-(phenylethynyl)benzenesulfonamide (888488-10-6)

Guidance literature:

N-(2,2-dichlorovinyl)-N-(pent-4-enyl)-p-toluenesulfonamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

With zinc dibromide; In tetrahydrofuran; hexane; at 20 ℃;

iodobenzene; With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; hexane; at 20 ℃;

DOI:10.1016/j.tet.2005.11.083

Reference yield:

N-(4-bromopent-4-en-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide (1361582-88-8) → 4-methyl-N-(pent-4-en-1-yl)-N-(phenylethynyl)benzenesulfonamide (888488-10-6) + (Z)-2-benzylidene-3-methylene-1-tosylpiperidine (1443365-64-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 80 ℃; for 1h;

DOI:10.1002/adsc.201200703

Reference yield:

N-(4-bromopent-4-en-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide (1361582-88-8) → 4-methyl-N-(pent-4-en-1-yl)-N-(phenylethynyl)benzenesulfonamide (888488-10-6) + C20H21NO2S

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In ethanol; at 80 ℃; for 0.25h; Overall yield = 71 %;

DOI:10.1002/chem.201501710

upstream raw materials:

iodobenzene

N-(2,2-dichlorovinyl)-N-(pent-4-enyl)-p-toluenesulfonamide

n-Pent-4-enyl alcohol

N-formyl-N-tosylamide