N-(4-methylphenyl)sulfonylformamide

Base Information

• Chemical Name: N-(4-methylphenyl)sulfonylformamide
• CAS No.: 4917-56-0
• Molecular Formula: C8H9NO3S
• Molecular Weight: 199.23
• Mol file: 4917-56-0.mol

Synonyms:N-formyl-p-toluenesulfonamide;N-formyl-toluenesulfonamide;N-Formyltiluenesulfonamide;Benzenesulfonamide,N-formyl-4-methyl;N-formyl-4-methylbenzenesulfonamide;N-formyl-p-toluenesulphonamide;N-formyl-N-tosylamide;

Chemical Property of N-(4-methylphenyl)sulfonylformamide

Chemical Property:

• PSA: 75.11000
• LogP: 2.35080

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-methylphenyl)sulfonylformamide

There total 9 articles about N-(4-methylphenyl)sulfonylformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-(2-(4-(diethylamino)phenyl)-2-phenylvinyl)-4-methylbenzenesulfonamide → (4-(diethylamino)phenyl)(phenyl)methanone (18127-87-2) + N-formyl-N-tosylamide (4917-56-0)

Guidance literature:

With oxygen; caesium carbonate; In toluene; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.joc.7b03068

Reference yield: 94.0%

toluene-4-sulfonamide (70-55-3) + formic acid ethyl ester (109-94-4) → N-formyl-N-tosylamide (4917-56-0)

Guidance literature:

With sodium; In methanol; at 40 - 50 ℃;

DOI:10.1055/s-0036-1588820

Reference yield: 63.0%

N-(2-(azulen-1-yl)-2-phenylvinyl)-tolylsulfonamide → azulen-1-yl(phenyl)methanone (38717-96-3) + N-formyl-N-tosylamide (4917-56-0)

Guidance literature:

With oxygen; potassium carbonate; In toluene; at 70 ℃; for 9h; UV-irradiation;

DOI:10.1021/acs.orglett.5b02545

upstream raw materials:

4-toluenesulfonyl azide

2-methyl-3-oxobutanal

diethyl 2-(hydroxymethylene)malonate

N¹,N¹-diethyl-N²-4-tolylsulfonylformamidine

Downstream raw materials:

N-(2,2-dichlorovinyl)-N-(pent-4-enyl)-p-toluenesulfonamide

N-(but-3-enyl)-N-(2,2-dichlorovinyl)-p-toluenesulfonamide

N-(2,2-dichlorovinyl)-N-(2,2-dimethylpent-4-enyl)-p-toluenesulfonamide

N-(2,2-dichlorovinyl)-4-methyl-N-[3-(5-methylfuran-2-yl)propyl]benzenesulfonamide

Refernces

• 1、 Zhao, Yulei,Yuan, Yang,Kong, Lingkai,Zhang, Fangfang,Li, Yanzhong. "Synthesis of 1-Alkyl-3-(2-oxo-2-aryl/alkyl-ethyl)indolin-2-ones through Gold/Bronsted Acid Relay Actions: Observation of Selective C=C Bond Cleavage of Enaminones". . p. 3609 - 3618. Retrieved 2017/08/15.
• 2、 Brückner, David. "Synthesis of ynamides from formamides". . p. 3809 - 3814. Retrieved 2007/10/03.