4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester

Base Information

Chemical Name:4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester
CAS No.:157973-94-9
Molecular Formula:C₂₂H₂₅N₃O₄
Molecular Weight:395.458
Hs Code.:

Synonyms:4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester

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Chemical Property of 4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester

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Technology Process of 4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester

There total 6 articles about 4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-{Benzyloxycarbonyl-[2-((S)-1-carbamoyl-2-phenyl-ethylamino)-ethyl]-amino}-propionic acid

: 157973-94-9
4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; Yield given; Ambient temperature;
DOI:10.1021/jm00037a005

Reference yield:

: 5241-58-7
L-Phenylalanine amide

: 157973-94-9
4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) AcOH, 2.) sodium cyanoborohydride / 1.) CH₃CN, RT, 20 min, 2.) CH₃CN, RT, overnight

2: K₂CO₃ / methanol; H₂O / 3 h / Heating

3: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

With sodium cyanoborohydride; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; water;
DOI:10.1021/jm00037a005

Reference yield:

: 10494-76-5
3-(2-hydroxyethylamino)propionic acid methyl ester

: 157973-94-9
4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaHCO₃, 1 N aq. NaOH / tetrahydrofuran / Ambient temperature

2: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) CH₂Cl₂, -78 deg C, 10 min

3: 1.) AcOH, 2.) sodium cyanoborohydride / 1.) CH₃CN, RT, 20 min, 2.) CH₃CN, RT, overnight

4: K₂CO₃ / methanol; H₂O / 3 h / Heating

5: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; oxalyl dichloride; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00037a005