1-(4-methoxyphenyl)-7-oxo-6-[5-(2-oxo-1-piperidinyl)-2-pyridinyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide trifluoroacetate

Base Information

Chemical Name:1-(4-methoxyphenyl)-7-oxo-6-[5-(2-oxo-1-piperidinyl)-2-pyridinyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide trifluoroacetate
CAS No.:503615-22-3
Molecular Formula:C₂HF₃O₂*C₂₄H₂₄N₆O₄
Molecular Weight:574.516
Hs Code.:

Synonyms:1-(4-methoxyphenyl)-7-oxo-6-[5-(2-oxo-1-piperidinyl)-2-pyridinyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide trifluoroacetate

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Chemical Property of 1-(4-methoxyphenyl)-7-oxo-6-[5-(2-oxo-1-piperidinyl)-2-pyridinyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide trifluoroacetate

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Technology Process of 1-(4-methoxyphenyl)-7-oxo-6-[5-(2-oxo-1-piperidinyl)-2-pyridinyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide trifluoroacetate

There total 8 articles about 1-(4-methoxyphenyl)-7-oxo-6-[5-(2-oxo-1-piperidinyl)-2-pyridinyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: C₂₆H₂₇N₅O₅

: 76-05-1
trifluoroacetic acid

: 503615-22-3
1-(4-methoxyphenyl)-7-oxo-6-[5-(2-oxo-1-piperidinyl)-2-pyridinyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide trifluoroacetate

Guidance literature:: C₂₆H₂₇N₅O₅; With sodium methylate; formamide; In methanol; N,N-dimethyl-formamide; for 24h;

trifluoroacetic acid;

Reference yield:

: 207976-92-9
3-chloro-5,6-dihydro-1H-pyridin-2-one

: 503615-22-3
1-(4-methoxyphenyl)-7-oxo-6-[5-(2-oxo-1-piperidinyl)-2-pyridinyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / toluene / 24 h / Reflux

2.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 24 h / 75 °C / Inert atmosphere

3.1: iron; acetic acid / 1,4-dioxane / 1.5 h / 90 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 24 h

4.2: 72 h

5.1: formamide; sodium methylate / N,N-dimethyl-formamide; methanol / 24 h

With sodium methylate; palladium diacetate; iron; caesium carbonate; formamide; acetic acid; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 503614-56-0
1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxylic acid ethyl ester

: 503615-22-3
1-(4-methoxyphenyl)-7-oxo-6-[5-(2-oxo-1-piperidinyl)-2-pyridinyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 24 h / 75 °C / Inert atmosphere

2.1: iron; acetic acid / 1,4-dioxane / 1.5 h / 90 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 24 h

3.2: 72 h

4.1: formamide; sodium methylate / N,N-dimethyl-formamide; methanol / 24 h

With sodium methylate; palladium diacetate; iron; caesium carbonate; formamide; acetic acid; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;