(2,6-difluorophenyl)(3,5-diisopropoxyphenyl)methanone

Base Information

Chemical Name:(2,6-difluorophenyl)(3,5-diisopropoxyphenyl)methanone
CAS No.:1370519-94-0
Molecular Formula:C₁₉H₂₀F₂O₃
Molecular Weight:334.363
Hs Code.:

Synonyms:(2,6-difluorophenyl)(3,5-diisopropoxyphenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2,6-difluorophenyl)(3,5-diisopropoxyphenyl)methanone

Chemical Property:

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Technology Process of (2,6-difluorophenyl)(3,5-diisopropoxyphenyl)methanone

There total 4 articles about (2,6-difluorophenyl)(3,5-diisopropoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1370519-93-9
(2,6-difluorophenyl)(3,5-diisopropoxyphenyl)methanol

: 1370519-94-0
(2,6-difluorophenyl)(3,5-diisopropoxyphenyl)methanone

Guidance literature:: With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; triphenylphosphine; lithium hydroxide; In toluene; for 48h; Reflux; Inert atmosphere;
DOI:10.1039/c2dt12271e

Reference yield:

: 106120-04-1
5-bromoresorcinol

: 1370519-94-0
(2,6-difluorophenyl)(3,5-diisopropoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / Reflux; Inert atmosphere

2.1: tert.-butyl lithium / diethyl ether / 3 h / -78 °C / Inert atmosphere

2.2: 5 h / -78 - 20 °C / Inert atmosphere

3.1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; triphenylphosphine; lithium hydroxide / toluene / 48 h / Reflux; Inert atmosphere

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; tert.-butyl lithium; potassium carbonate; triphenylphosphine; lithium hydroxide; In diethyl ether; acetone; toluene;
DOI:10.1039/c2dt12271e

Reference yield:

: 20469-65-2
1-bromo-3,5-dimethoxybenzene

: 1370519-94-0
(2,6-difluorophenyl)(3,5-diisopropoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 48 h / -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate / acetone / Reflux; Inert atmosphere

3.1: tert.-butyl lithium / diethyl ether / 3 h / -78 °C / Inert atmosphere

3.2: 5 h / -78 - 20 °C / Inert atmosphere

4.1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; triphenylphosphine; lithium hydroxide / toluene / 48 h / Reflux; Inert atmosphere

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; tert.-butyl lithium; boron tribromide; potassium carbonate; triphenylphosphine; lithium hydroxide; In diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1039/c2dt12271e