6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile

Base Information

Chemical Name:6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile
CAS No.:1431943-79-1
Molecular Formula:C₂₅H₂₄FN₃O₅
Molecular Weight:465.481
Hs Code.:

Synonyms:6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile

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Chemical Property of 6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile

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Technology Process of 6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile

There total 6 articles about 6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1255206-70-2
4-methyl-5-[2R-oxiran-2-yl]-2-benzofuran-1(3H)-one

: 1431944-43-2
6-fluoro-2-methyl-3-[{2-oxopiperazin-1-yl}acetyl]benzonitrile

: 1431943-79-1
6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile

Guidance literature:: In ethanol; at 140 ℃; for 1h;

Reference yield:

: 1255206-69-9
5-ethenyl-4-methyl-2-benzofuran-1(3H)-one

: 1431943-79-1
6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2: ChiralPak? AD-H column / methanol; ethanol; dichloromethane / 25 °C / 75007.5 Torr / Resolution of racemate

3: ethanol / 1 h / 140 °C

With 3-chloro-benzenecarboperoxoic acid; In methanol; ethanol; dichloromethane;

Reference yield:

: 76006-33-2
3-bromo-2-methylbenzoic acid

: 1431943-79-1
6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 24 h

2.1: trifluoroacetic acid; thallium(III) trifluoroacetate / 20 °C

2.2: 2 h / 20 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / ethanol / 0.33 h / 140 °C / Microwave irradiation; Sealed tube

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5.1: ChiralPak? AD-H column / methanol; ethanol; dichloromethane / 25 °C / 75007.5 Torr / Resolution of racemate

6.1: ethanol / 1 h / 140 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; borane-THF; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; thallium(III) trifluoroacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane;