5-(diphenylphosphino)isophthalic acid

Base Information

• Chemical Name: 5-(diphenylphosphino)isophthalic acid
• CAS No.: 182616-51-9
• Molecular Formula: C₂₀H₁₅O₄P
• Molecular Weight: 350.31
• Mol file: 182616-51-9.mol

Synonyms:5-(diphenylphosphino)isophthalic acid

Chemical Property of 5-(diphenylphosphino)isophthalic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 5-(diphenylphosphino)isophthalic acid

There total 2 articles about 5-(diphenylphosphino)isophthalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5-iodoisophthalic acid (51839-16-8) + diphenylphosphane (829-85-6) → 5-(diphenylphosphino)isophthalic acid (182616-51-9)

Guidance literature:

With palladium diacetate; triethylamine; In acetonitrile; at 90 ℃; for 12h;

DOI:10.1016/0022-328X(96)06136-0

Reference yield:

5-aminoisophthalic acid (99-31-0) → 5-(diphenylphosphino)isophthalic acid (182616-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C

1.2: 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; palladium diacetate / acetonitrile / Reflux; Inert atmosphere

With hydrogenchloride; palladium diacetate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In water; acetonitrile;

DOI:10.1002/ejoc.201301011

Reference yield: 55.0%

C17H22FeN2O + 5-(diphenylphosphino)isophthalic acid (182616-51-9) → C54H55Fe2N4O4P

Guidance literature:

5-(diphenylphosphino)isophthalic acid; With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

C₁₇H₂₂FeN₂O; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1002/ejoc.201801647

upstream raw materials:

5-iodoisophthalic acid

diphenylphosphane

5-aminoisophthalic acid

Downstream raw materials:

C₂₀H₁₅O₅P