(1R,3aS,7aR)-4(E)-{2-[(R)-3-((R)-(tert-butyldimethylsilyloxy))-5-(tert-butyldimethylsilyloxy)cyclohexylidene]ethylidene}-7a-methyl-1-[(1S,4R)-5-methyl-1-(4-methyl-4-(triethylsilanyloxy)pentyl)-4,5-bis(triethylsilanyloxy)hexyl]octahydroindene

Base Information

Chemical Name:(1R,3aS,7aR)-4(E)-{2-[(R)-3-((R)-(tert-butyldimethylsilyloxy))-5-(tert-butyldimethylsilyloxy)cyclohexylidene]ethylidene}-7a-methyl-1-[(1S,4R)-5-methyl-1-(4-methyl-4-(triethylsilanyloxy)pentyl)-4,5-bis(triethylsilanyloxy)hexyl]octahydroindene
CAS No.:770714-54-0
Molecular Formula:C₆₂H₁₂₄O₅Si₅
Molecular Weight:1090.09
Hs Code.:

(1R,3aS,7aR)-4(E)-{2-[(R)-3-((R)-(tert-butyldimethylsilyloxy))-5-(tert-butyldimethylsilyloxy)cyclohexylidene]ethylidene}-7a-methyl-1-[(1S,4R)-5-methyl-1-(4-methyl-4-(triethylsilanyloxy)pentyl)-4,5-bis(triethylsilanyloxy)hexyl]octahydroindene

Synonyms:(1R,3aS,7aR)-4(E)-{2-[(R)-3-((R)-(tert-butyldimethylsilyloxy))-5-(tert-butyldimethylsilyloxy)cyclohexylidene]ethylidene}-7a-methyl-1-[(1S,4R)-5-methyl-1-(4-methyl-4-(triethylsilanyloxy)pentyl)-4,5-bis(triethylsilanyloxy)hexyl]octahydroindene

Suppliers and Price of (1R,3aS,7aR)-4(E)-{2-[(R)-3-((R)-(tert-butyldimethylsilyloxy))-5-(tert-butyldimethylsilyloxy)cyclohexylidene]ethylidene}-7a-methyl-1-[(1S,4R)-5-methyl-1-(4-methyl-4-(triethylsilanyloxy)pentyl)-4,5-bis(triethylsilanyloxy)hexyl]octahydroindene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,3aS,7aR)-4(E)-{2-[(R)-3-((R)-(tert-butyldimethylsilyloxy))-5-(tert-butyldimethylsilyloxy)cyclohexylidene]ethylidene}-7a-methyl-1-[(1S,4R)-5-methyl-1-(4-methyl-4-(triethylsilanyloxy)pentyl)-4,5-bis(triethylsilanyloxy)hexyl]octahydroindene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,3aS,7aR)-4(E)-{2-[(R)-3-((R)-(tert-butyldimethylsilyloxy))-5-(tert-butyldimethylsilyloxy)cyclohexylidene]ethylidene}-7a-methyl-1-[(1S,4R)-5-methyl-1-(4-methyl-4-(triethylsilanyloxy)pentyl)-4,5-bis(triethylsilanyloxy)hexyl]octahydroindene

There total 13 articles about (1R,3aS,7aR)-4(E)-{2-[(R)-3-((R)-(tert-butyldimethylsilyloxy))-5-(tert-butyldimethylsilyloxy)cyclohexylidene]ethylidene}-7a-methyl-1-[(1S,4R)-5-methyl-1-(4-methyl-4-(triethylsilanyloxy)pentyl)-4,5-bis(triethylsilanyloxy)hexyl]octahydroindene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 81522-68-1
[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

: 770714-47-1
(1R,3aR,7aR)-7a-methyl-1-[(1S,4R)-5-methyl-1-(4-methyl-4-(triethylsilanyloxy)pentyl)-4,5-bis(triethylsilanyloxy)hexyl]octahydroinden-4-one

: 770714-54-0
(1R,3aS,7aR)-4(E)-{2-[(R)-3-((R)-(tert-butyldimethylsilyloxy))-5-(tert-butyldimethylsilyloxy)cyclohexylidene]ethylidene}-7a-methyl-1-[(1S,4R)-5-methyl-1-(4-methyl-4-(triethylsilanyloxy)pentyl)-4,5-bis(triethylsilanyloxy)hexyl]octahydroindene

Guidance literature:: [(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 0.166667h;

(1R,3aR,7aR)-7a-methyl-1-[(1S,4R)-5-methyl-1-(4-methyl-4-(triethylsilanyloxy)pentyl)-4,5-bis(triethylsilanyloxy)hexyl]octahydroinden-4-one; In tetrahydrofuran; hexane; at -78 ℃; for 3h;
DOI:10.1021/jm049340b

Reference yield:

: 792959-68-3
(3R,6R)-6-[(1R,3aR,4S,7aR)-4-(tert-butyldimethylsilanyloxy)-7a-methyloctahydroinden-1-yl]-2,10-dimethylundecane-2,3,10-triol

: 770714-54-0
(1R,3aS,7aR)-4(E)-{2-[(R)-3-((R)-(tert-butyldimethylsilyloxy))-5-(tert-butyldimethylsilyloxy)cyclohexylidene]ethylidene}-7a-methyl-1-[(1S,4R)-5-methyl-1-(4-methyl-4-(triethylsilanyloxy)pentyl)-4,5-bis(triethylsilanyloxy)hexyl]octahydroindene

Guidance literature:: Multi-step reaction with 6 steps

1.1: 79 percent / aq. fluorosilic acid / acetonitrile / 2.5 h

2.1: 100 percent / pyridinium tosylate / CH₂Cl₂ / 5.75 h

3.1: 91 percent / pyridinium dichromate; Celite / CH₂Cl₂ / 2.5 h

4.1: 94 percent / aq. oxalic acid / methanol / 1.25 h

5.1: 78.4 percent / imidazole; N,N-dimethylpyridine / dimethylformamide / 17 h

6.1: BuLi / hexane; tetrahydrofuran / 0.17 h / -70 °C

6.2: 57 percent / hexane; tetrahydrofuran / 3 h / -78 °C

With 1H-imidazole; dipyridinium dichromate; n-butyllithium; N,N-dimethylpyridine; Celite; fluorosilic acid; pyridinium p-toluenesulfonate; oxalic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 6.2: Wittig-Horner reaction;
DOI:10.1021/jm049340b

Reference yield:

: 770714-50-6
(3R,6S)-6-((1R,3aR,4S,7aR)-4-hydroxy-7a-methyloctahydroinden-1-yl)-2,10-dimethylundecane-2,3,10-triol

: 770714-54-0
(1R,3aS,7aR)-4(E)-{2-[(R)-3-((R)-(tert-butyldimethylsilyloxy))-5-(tert-butyldimethylsilyloxy)cyclohexylidene]ethylidene}-7a-methyl-1-[(1S,4R)-5-methyl-1-(4-methyl-4-(triethylsilanyloxy)pentyl)-4,5-bis(triethylsilanyloxy)hexyl]octahydroindene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / pyridinium tosylate / CH₂Cl₂ / 5.75 h

2.1: 91 percent / pyridinium dichromate; Celite / CH₂Cl₂ / 2.5 h

3.1: 94 percent / aq. oxalic acid / methanol / 1.25 h

4.1: 78.4 percent / imidazole; N,N-dimethylpyridine / dimethylformamide / 17 h

5.1: BuLi / hexane; tetrahydrofuran / 0.17 h / -70 °C

5.2: 57 percent / hexane; tetrahydrofuran / 3 h / -78 °C

With 1H-imidazole; dipyridinium dichromate; n-butyllithium; N,N-dimethylpyridine; Celite; pyridinium p-toluenesulfonate; oxalic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 5.2: Wittig-Horner reaction;
DOI:10.1021/jm049340b