(3R,4R)-4-((S)-1-Methoxymethyl-allyl)-3-methyl-3-((E)-3-phenyl-propenyl)-1-(toluene-4-sulfonyl)-pyrrolidine

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Chemical Name:(3R,4R)-4-((S)-1-Methoxymethyl-allyl)-3-methyl-3-((E)-3-phenyl-propenyl)-1-(toluene-4-sulfonyl)-pyrrolidine
CAS No.:705963-09-3
Molecular Formula:C₂₆H₃₃NO₃S
Molecular Weight:439.619
Hs Code.:

Synonyms:(3R,4R)-4-((S)-1-Methoxymethyl-allyl)-3-methyl-3-((E)-3-phenyl-propenyl)-1-(toluene-4-sulfonyl)-pyrrolidine

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Chemical Property of (3R,4R)-4-((S)-1-Methoxymethyl-allyl)-3-methyl-3-((E)-3-phenyl-propenyl)-1-(toluene-4-sulfonyl)-pyrrolidine

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Technology Process of (3R,4R)-4-((S)-1-Methoxymethyl-allyl)-3-methyl-3-((E)-3-phenyl-propenyl)-1-(toluene-4-sulfonyl)-pyrrolidine

There total 2 articles about (3R,4R)-4-((S)-1-Methoxymethyl-allyl)-3-methyl-3-((E)-3-phenyl-propenyl)-1-(toluene-4-sulfonyl)-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74-88-4
methyl iodide

: (S)-2-[(3R,4R)-4-Methyl-4-((E)-3-phenyl-propenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-3-yl]-but-3-en-1-ol

: 705963-09-3
(3R,4R)-4-((S)-1-Methoxymethyl-allyl)-3-methyl-3-((E)-3-phenyl-propenyl)-1-(toluene-4-sulfonyl)-pyrrolidine

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/ja049506y

Reference yield:

: 705962-78-3
methyl (2S)-2-{(3R,4R)-4-methyl-1-[(1E)-phenylprop-1-enyl]-(4-methylbenzenesulfonyl)pyrrolidin-3-yl}but-3-enoate

: 705963-09-3
(3R,4R)-4-((S)-1-Methoxymethyl-allyl)-3-methyl-3-((E)-3-phenyl-propenyl)-1-(toluene-4-sulfonyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / 0.5 h / 0 °C

2: NaH / tetrahydrofuran; dimethylformamide / 2 h / 20 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ja049506y

Reference yield:

: 705963-09-3
(3R,4R)-4-((S)-1-Methoxymethyl-allyl)-3-methyl-3-((E)-3-phenyl-propenyl)-1-(toluene-4-sulfonyl)-pyrrolidine

: (R)-2-[(3R,4R)-4-Hydroxymethyl-4-methyl-1-(toluene-4-sulfonyl)-pyrrolidin-3-yl]-3-methoxy-propan-1-ol

Guidance literature:: (3R,4R)-4-((S)-1-Methoxymethyl-allyl)-3-methyl-3-((E)-3-phenyl-propenyl)-1-(toluene-4-sulfonyl)-pyrrolidine; With ozone; In diethyl ether; at -78 ℃; for 0.25h;

With lithium aluminium tetrahydride; In diethyl ether; at -78 - 20 ℃;
DOI:10.1021/ja049506y