ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE

Base Information

• Chemical Name: ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE
• CAS No.: 1009306-55-1
• Molecular Formula: C₁₉H₁₆ClNO₂*ClH
• Molecular Weight: 362.255
• Hs Code.: 29334900
• Mol file: 1009306-55-1.mol

Synonyms:2-chloromethyl-4-phenyl-3-quinolinecarboxylic acid ethyl ester hydrochloride

Chemical Property of ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE

Chemical Property:

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Ethyl2-(Chloromethyl)-4-phenylquinoline-3-carboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE

There total 1 articles about ETHYL 2-(CHLOROMETHYL)-4-PHENYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl (2-chloroaceto)acetate (638-07-3) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 2-chloromethyl-4-phenyl-3-quinolinecarboxylic acid ethyl ester hydrochloride (1009306-55-1)

Guidance literature:

With chloro-trimethyl-silane; In N,N-dimethyl-formamide; at 60 - 80 ℃; for 1h;

DOI:10.1055/s-2007-990869

Reference yield: 98.0%

2-chloromethyl-4-phenyl-3-quinolinecarboxylic acid ethyl ester hydrochloride (1009306-55-1) + 2-hydroxyethanethiol (60-24-2) → 2-[(2-hydroxyethyl)thio]methyl-4-phenyl-3-quinolinecarboxylic acid ethyl ester (1009306-68-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

DOI:10.1055/s-2007-990869

Reference yield: 95.0%

2-chloromethyl-4-phenyl-3-quinolinecarboxylic acid ethyl ester hydrochloride (1009306-55-1) + potassium cyanide (151-50-8) → 2-cyanomethyl-4-phenyl-3-quinolinecarboxylic acid ethyl ester (1009306-63-1)

Guidance literature:

In N,N-dimethyl-formamide; at 45 ℃; for 3h;

DOI:10.1055/s-2007-990869

upstream raw materials:

ethyl (2-chloroaceto)acetate

(2-aminophenyl)(phenyl)methanone

Downstream raw materials:

2-cyanomethyl-4-phenyl-3-quinolinecarboxylic acid ethyl ester

2-[(2-hydroxyethyl)thio]methyl-4-phenyl-3-quinolinecarboxylic acid ethyl ester

Refernces