(2S,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol

Base Information

Chemical Name:(2S,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol
CAS No.:1159099-71-4
Molecular Formula:C₂₈H₃₂F₂O₅
Molecular Weight:486.556
Hs Code.:

Synonyms:(2S,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol

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Chemical Property of (2S,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol

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Technology Process of (2S,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol

There total 1 articles about (2S,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1159099-69-0
((2S,3R,E)-4,4-difluoro-3-vunyloct-6-ene-1,2,5-triyl)tris(oxy)tris(methylene)tribenzene

: 1159099-71-4
(2S,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol

: 1159099-70-3
(2R,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol

Guidance literature:: ((2S,3R,E)-4,4-difluoro-3-vunyloct-6-ene-1,2,5-triyl)tris(oxy)tris(methylene)tribenzene; With ozone; In methanol; dichloromethane; at -78 ℃;

With sodium tetrahydroborate; In methanol; dichloromethane; for 1h;

With water; ammonium chloride; In methanol; dichloromethane;
DOI:10.1016/j.tet.2009.02.079

Reference yield: 84.0%

: 1159099-71-4
(2S,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol

: 100-46-9
benzylamine

: 1159099-73-6
(3S,5R)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4,4-difluoropiperidine

Guidance literature:: (2S,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol; With dmap; methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃;

benzylamine; at 80 ℃; for 18h;
DOI:10.1016/j.tet.2009.02.079

Reference yield: 68.0%

: 1159099-71-4
(2S,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol

: 109-73-9,85404-21-3
N-butylamine

: 1159099-75-8
(3S,5R)3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-1-butyl-4,4-difluoropiperidine

Guidance literature:: (2S,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol; With dmap; methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃;

N-butylamine; for 18h; Reflux;
DOI:10.1016/j.tet.2009.02.079