3-{6-(4-methoxyphenyl)-3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-yl}-1H-indole

Base Information

Chemical Name:3-{6-(4-methoxyphenyl)-3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-yl}-1H-indole
CAS No.:1451188-33-2
Molecular Formula:C₃₄H₃₂N₂O₃S
Molecular Weight:548.706
Hs Code.:

Synonyms:3-{6-(4-methoxyphenyl)-3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-yl}-1H-indole

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Chemical Property of 3-{6-(4-methoxyphenyl)-3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-yl}-1H-indole

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Technology Process of 3-{6-(4-methoxyphenyl)-3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-yl}-1H-indole

There total 4 articles about 3-{6-(4-methoxyphenyl)-3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-yl}-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 120-72-9
indole

: 1451188-11-6
N-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(2-phenylprop-2-en-1-yl)benzenesulfonamide

: N-({2-[3,3-bis(1H-indol-3-yl)propyl]-2-(4-methoxyphenyl)-1-phenylcyclopropyl}methyl)-4-methylbenzenesulfonamide

: 1451188-33-2
3-{6-(4-methoxyphenyl)-3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-yl}-1H-indole

Guidance literature:: With platinum(II) chloride; In toluene; at 80 ℃; for 3.5h;
DOI:10.1002/chem.201202647

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: N-({2-[3,3-bis(1H-indol-3-yl)propyl]-2-(4-methoxyphenyl)-1-phenylcyclopropyl}methyl)-4-methylbenzenesulfonamide

: 1451188-33-2
3-{6-(4-methoxyphenyl)-3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-yl}-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 15 h / 20 °C / Cooling with ice

2: triphenylphosphine; triethylamine; copper(l) iodide; palladium diacetate / N,N-dimethyl-formamide / 14 h

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; potassium carbonate / acetonitrile / 24 h / 80 °C / 375.04 Torr / Schlenk technique; Sealed tube

4: platinum(II) chloride / toluene / 3.5 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; trifuran-2-yl-phosphane; palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; platinum(II) chloride; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 2: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201202647

Reference yield:

: 1239173-02-4
N-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-methylbenzenesulfonamide

: N-({2-[3,3-bis(1H-indol-3-yl)propyl]-2-(4-methoxyphenyl)-1-phenylcyclopropyl}methyl)-4-methylbenzenesulfonamide

: 1451188-33-2
3-{6-(4-methoxyphenyl)-3-[(4-methylphenyl)sulfonyl]-1-phenyl-3-azabicyclo[4.1.0]hept-4-yl}-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; potassium carbonate / acetonitrile / 24 h / 80 °C / 375.04 Torr / Schlenk technique; Sealed tube

2: platinum(II) chloride / toluene / 3.5 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; potassium carbonate; platinum(II) chloride; In toluene; acetonitrile;
DOI:10.1002/chem.201202647