N-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(2-phenylprop-2-en-1-yl)benzenesulfonamide

Base Information

Chemical Name:N-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(2-phenylprop-2-en-1-yl)benzenesulfonamide
CAS No.:1451188-11-6
Molecular Formula:C₂₆H₂₅NO₃S
Molecular Weight:431.555
Hs Code.:

Synonyms:N-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(2-phenylprop-2-en-1-yl)benzenesulfonamide

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Chemical Property of N-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(2-phenylprop-2-en-1-yl)benzenesulfonamide

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Technology Process of N-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(2-phenylprop-2-en-1-yl)benzenesulfonamide

There total 3 articles about N-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(2-phenylprop-2-en-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 591-50-4
iodobenzene

: 463-49-0
1,2-propanediene

: 1239173-02-4
N-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-methylbenzenesulfonamide

: 1451188-11-6
N-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(2-phenylprop-2-en-1-yl)benzenesulfonamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; potassium carbonate; In acetonitrile; at 80 ℃; for 24h; under 375.038 Torr; Schlenk technique; Sealed tube;
DOI:10.1002/chem.201202647

Reference yield:

: 55022-46-3
4-methyl-N-prop-2-ynylbenzenesulfonamide

: 1451188-11-6
N-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(2-phenylprop-2-en-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; triethylamine; copper(l) iodide; palladium diacetate / N,N-dimethyl-formamide / 14 h

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; potassium carbonate / acetonitrile / 24 h / 80 °C / 375.04 Torr / Schlenk technique; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; trifuran-2-yl-phosphane; palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; acetonitrile; 1: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201202647

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1451188-11-6
N-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-methyl-N-(2-phenylprop-2-en-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 15 h / 20 °C / Cooling with ice

2: triphenylphosphine; triethylamine; copper(l) iodide; palladium diacetate / N,N-dimethyl-formamide / 14 h

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; potassium carbonate / acetonitrile / 24 h / 80 °C / 375.04 Torr / Schlenk technique; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; trifuran-2-yl-phosphane; palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201202647