N-(2-(3-aminopropoxy)-7-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

Base Information

Chemical Name:N-(2-(3-aminopropoxy)-7-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide
CAS No.:1567351-05-6
Molecular Formula:C₃₆H₄₃N₃O₉
Molecular Weight:661.752
Hs Code.:

N-(2-(3-aminopropoxy)-7-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

Synonyms:N-(2-(3-aminopropoxy)-7-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

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Chemical Property of N-(2-(3-aminopropoxy)-7-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

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Technology Process of N-(2-(3-aminopropoxy)-7-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

There total 16 articles about N-(2-(3-aminopropoxy)-7-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1567351-03-4
C₄₃H₄₉N₃O₉

: 1567351-05-6
N-(2-(3-aminopropoxy)-7-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2013.12.056

Reference yield:

: 1567350-99-5
N-(2-(3-bromopropoxy)-7-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

: 1567351-05-6
N-(2-(3-aminopropoxy)-7-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 16 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.12.056

Reference yield:

: 154521-00-3
7-hydroxy-8-methylquinolin-2(1H)-one

: 1567351-05-6
N-(2-(3-aminopropoxy)-7-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C

3: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C

4: sodium azide; ascorbic acid; pipecolic Acid / N,N-dimethyl acetamide / 15 h / 100 °C / Sealed tube

5: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 20 °C

6: palladium 10% on activated carbon; hydrogen / ethyl acetate / 6 h

7: boron trifluoride diethyl etherate / dichloromethane / 20 °C

8: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

9: triethylamine; methanol / 14 h

10: N,N-dimethyl-formamide / 16 h / 20 °C

11: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C

With pyridine; methanol; N-Bromosuccinimide; sodium azide; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; pipecolic Acid; ascorbic acid; In dichloromethane; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.12.056