N-(2-(3-bromopropoxy)-7-(((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-4-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

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Chemical Name:N-(2-(3-bromopropoxy)-7-(((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-4-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide
CAS No.:1567350-97-3
Molecular Formula:C₃₇H₃₉BrN₂O₁₀
Molecular Weight:751.628
Hs Code.:

N-(2-(3-bromopropoxy)-7-(((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-4-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

Synonyms:N-(2-(3-bromopropoxy)-7-(((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-4-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

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Chemical Property of N-(2-(3-bromopropoxy)-7-(((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-4-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

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Technology Process of N-(2-(3-bromopropoxy)-7-(((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-4-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

There total 13 articles about N-(2-(3-bromopropoxy)-7-(((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-4-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1567350-78-0
N-(2-hydroxy-7-(((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-4-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

: 109-64-8
1,3-dibromo-propane

: 1567350-97-3
N-(2-(3-bromopropoxy)-7-(((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-4-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1016/j.bmc.2013.12.056

Reference yield:

: 154521-00-3
7-hydroxy-8-methylquinolin-2(1H)-one

: 1567350-97-3
N-(2-(3-bromopropoxy)-7-(((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-4-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C

3: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C

4: sodium azide; ascorbic acid; pipecolic Acid / N,N-dimethyl acetamide / 15 h / 100 °C / Sealed tube

5: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 20 °C

6: palladium 10% on activated carbon; hydrogen / ethyl acetate / 6 h

7: boron trifluoride diethyl etherate / dichloromethane / 20 °C

8: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

With pyridine; N-Bromosuccinimide; sodium azide; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pipecolic Acid; ascorbic acid; In dichloromethane; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.12.056

Reference yield:

: 1567348-80-4
7-(benzyloxy)-8-methylquinolin-2(1H)-one

: 1567350-97-3
N-(2-(3-bromopropoxy)-7-(((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-4-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C

2: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C

3: sodium azide; ascorbic acid; pipecolic Acid / N,N-dimethyl acetamide / 15 h / 100 °C / Sealed tube

4: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 6 h

6: boron trifluoride diethyl etherate / dichloromethane / 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

With pyridine; N-Bromosuccinimide; sodium azide; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pipecolic Acid; ascorbic acid; In dichloromethane; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.12.056