4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-((1R,2R)-2-ethoxycarbonyl-cyclopropylmethyl)pyrrolidine-2-carbonyl]amino}-3-methoxy-benzoic acid

Base Information

Chemical Name:4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-((1R,2R)-2-ethoxycarbonyl-cyclopropylmethyl)pyrrolidine-2-carbonyl]amino}-3-methoxy-benzoic acid
CAS No.:1354692-98-0
Molecular Formula:C₃₈H₃₉Cl₂F₂N₃O₆
Molecular Weight:742.647
Hs Code.:

4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-((1R,2R)-2-ethoxycarbonyl-cyclopropylmethyl)pyrrolidine-2-carbonyl]amino}-3-methoxy-benzoic acid

Synonyms:4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-((1R,2R)-2-ethoxycarbonyl-cyclopropylmethyl)pyrrolidine-2-carbonyl]amino}-3-methoxy-benzoic acid

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Chemical Property of 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-((1R,2R)-2-ethoxycarbonyl-cyclopropylmethyl)pyrrolidine-2-carbonyl]amino}-3-methoxy-benzoic acid

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Technology Process of 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-((1R,2R)-2-ethoxycarbonyl-cyclopropylmethyl)pyrrolidine-2-carbonyl]amino}-3-methoxy-benzoic acid

There total 5 articles about 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-((1R,2R)-2-ethoxycarbonyl-cyclopropylmethyl)pyrrolidine-2-carbonyl]amino}-3-methoxy-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354692-88-8
4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-(2-ethoxycarbonyl-cyclopropylmethyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid methyl ester

: 1354692-98-0
4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-((1R,2R)-2-ethoxycarbonyl-cyclopropylmethyl)pyrrolidine-2-carbonyl]amino}-3-methoxy-benzoic acid

: 1354692-97-9
4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-((1S,2S)-2-ethoxycarbonyl-cyclopropylmethyl)pyrrolidine-2-carbonyl]amino}-3-methoxy-benzoic acid

Guidance literature:: 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-(2-ethoxycarbonyl-cyclopropylmethyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid methyl ester; With lithium hydroxide; In tetrahydrofuran; at 20 - 50 ℃; for 72h;

With trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 41608-64-4
methyl 3-methoxy-4-aminobenzoate

: 1354692-98-0
4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-((1R,2R)-2-ethoxycarbonyl-cyclopropylmethyl)pyrrolidine-2-carbonyl]amino}-3-methoxy-benzoic acid

: 1354692-97-9
4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-((1S,2S)-2-ethoxycarbonyl-cyclopropylmethyl)pyrrolidine-2-carbonyl]amino}-3-methoxy-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 14 h / 25 °C

2: sodium tris(acetoxy)borohydride; acetic acid / 3.5 h

3: lithium hydroxide / tetrahydrofuran / 72 h / 20 - 50 °C

With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1219089-31-2
(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carboxylic acid

: 1354692-98-0
4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-((1R,2R)-2-ethoxycarbonyl-cyclopropylmethyl)pyrrolidine-2-carbonyl]amino}-3-methoxy-benzoic acid

: 1354692-97-9
4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-((1S,2S)-2-ethoxycarbonyl-cyclopropylmethyl)pyrrolidine-2-carbonyl]amino}-3-methoxy-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 14 h / 25 °C

2: sodium tris(acetoxy)borohydride; acetic acid / 3.5 h

3: lithium hydroxide / tetrahydrofuran / 72 h / 20 - 50 °C

With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; dichloromethane;