(2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanenitrile

Base Information

Chemical Name:(2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanenitrile
CAS No.:1144016-35-2
Molecular Formula:C₁₃H₁₀F₃N₃S
Molecular Weight:297.304
Hs Code.:

Synonyms:(2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanenitrile

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Chemical Property of (2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanenitrile

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Technology Process of (2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanenitrile

There total 1 articles about (2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1144016-15-8
DF₂₇₀₃Y

: 1144016-35-2
(2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 0.5 h / 0 - 50 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 - 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;
DOI:10.1016/j.tetlet.2013.09.022

Reference yield: 60.0%

: 1144016-35-2
(2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanenitrile

: 1144016-51-2
(2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propan imidamide

Guidance literature:: (2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanenitrile; With hydrogenchloride; In methanol; diethyl ether; at 20 ℃;

With ammonia; In methanol; at 20 ℃;

With hydrogenchloride; In dichloromethane; water;