methyl 3-[(4-{4-[amino(hydroxyimino)methyl]benzyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino]-2-benzyl-3-oxopropanoate

Base Information

• Chemical Name: methyl 3-[(4-{4-[amino(hydroxyimino)methyl]benzyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino]-2-benzyl-3-oxopropanoate
• CAS No.: 852233-50-2
• Molecular Formula: C₂₇H₂₆N₄O₆
• Molecular Weight: 502.527
• Mol file: 852233-50-2.mol

Synonyms:methyl 3-[(4-{4-[amino(hydroxyimino)methyl]benzyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino]-2-benzyl-3-oxopropanoate

Chemical Property of methyl 3-[(4-{4-[amino(hydroxyimino)methyl]benzyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino]-2-benzyl-3-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-[(4-{4-[amino(hydroxyimino)methyl]benzyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino]-2-benzyl-3-oxopropanoate

There total 8 articles about methyl 3-[(4-{4-[amino(hydroxyimino)methyl]benzyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino]-2-benzyl-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methyl 2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropanoate (852233-48-8) → methyl 3-[(4-{4-[amino(hydroxyimino)methyl]benzyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino]-2-benzyl-3-oxopropanoate (852233-50-2)

Guidance literature:

With hydroxylamine hydrochloride; In methanol; at 50 ℃;

DOI:10.1021/jm048984g

Reference yield:

2-benzyl-malonic acid benzyl ester methyl ester (607367-17-9) → methyl 3-[(4-{4-[amino(hydroxyimino)methyl]benzyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino]-2-benzyl-3-oxopropanoate (852233-50-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / tetrahydrofuran / 20 °C

2: 33 percent / N-methylmorpholine; 1-hydroxybezotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

3: 78 percent / hydroxylamine hydrochloride / methanol / 50 °C

With 4-methyl-morpholine; hydroxylamine hydrochloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm048984g

Reference yield:

4-[(7-nitro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methyl]benzonitrile (852233-49-9) → methyl 3-[(4-{4-[amino(hydroxyimino)methyl]benzyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino]-2-benzyl-3-oxopropanoate (852233-50-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / H₂ / Pd/C / dimethylformamide / 20 °C

2: 33 percent / N-methylmorpholine; 1-hydroxybezotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

3: 78 percent / hydroxylamine hydrochloride / methanol / 50 °C

With 4-methyl-morpholine; hydroxylamine hydrochloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm048984g

upstream raw materials:

methyl 2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropanoate

2-benzyl-malonic acid benzyl ester methyl ester

4-[(7-amino-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methyl]benzonitrile

4-[(7-nitro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methyl]benzonitrile