607367-17-9

Upstream product

• 52267-39-7 benzyl methyl malonate 
• 100-39-0 benzyl bromide 
• 186581-53-3 diazomethane 
• 3709-27-1 5-benzyl-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 100-51-6 benzyl alcohol 

Downstream Products

• 2612-30-8 2-benzyl-1,3-propanediol 
• 852233-60-4 diethyl (2S)-2-{[2-benzyl-3-oxo-3-({3-oxo-4-[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}pentanedioate 
• 853657-88-2 2-(2-{4-[4-(N-hydroxycarbamimidoyl)-benzyl]-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-ylcarbamoyl}-3-phenyl-propionylamino)-pentanedioic acid diethyl ester 
• 852233-70-6 (2S)-2-{[2-benzyl-3-oxo-3-({3-oxo-4[4-(5-oxo-4,5-dihydro-1,2,4-oxadiol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}pentanedioic acid 
• 852233-56-8 diethyl (2S)-2-[(2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropanoyl)amino]pentanedioate 
• 852233-59-1 2-(2-{3-oxo-4-[4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-benzyl]-3,4-dihydro-2H-benzo[1,4]oxazin-7-ylcarbamoyl}-3-phenyl-propionylamino)-propionic acid ethyl ester 
• 852233-58-0 ethyl 2-{[2benzyl-3-oxo-3-({3-oxo-4-[4-(5-oxo-4,5-dihydro-1,2,4-xodiazol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}acetate 
• 852233-61-5 ethyl 2-({3-[(4-{4-[amino(hydroxyimino)methyl]benzyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino]-2-benzyl-3-oxopropanoyl}amino)acetate 
• 852233-55-7 2-{2-[4-(4-cyano-benzyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-ylcarbamoyl]-3-phenyl-propionylamino}-propionic acid ethyl ester 
• 852233-54-6 ethyl [(2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropano-yl)amino]acetate 
• 852233-51-3 methyl 2-benzyl-3-oxo-3-({3-oxo-4-[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoate 
• 852233-50-2 methyl 3-[(4-{4-[amino(hydroxyimino)methyl]benzyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino]-2-benzyl-3-oxopropanoate 
• 852233-57-9 2-benzyl-N-[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]-3-oxo-β-alanine 
• 852233-48-8 methyl 2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropanoate 

Relevant academic research and scientific papers

Multi-catalysis cascade reactions based on the methoxycarbonylketene platform: Diversity-oriented synthesis of functionalized non-symmetrical malonates for agrochemicals and pharmaceuticals

In this paper we describe new multi-catalysis cascade (MCC) reactions for the one-pot synthesis of highly functionalized non-symmetrical malonates. These metal-free reactions are either five-step (olefination/hydrogenation/alkylation/ ketenization/esterif

Toward a novel class of antithrombotic compounds with dual function. Discovery of 1,4-benzoxazin-3(4H)-one derivatives possessing thrombin inhibitory and fibrinogen receptor antagonistic activities

A novel class of potential antithrombotic compounds with moderate thrombin inhibitory and fibrinogen receptor antagonistic activity is described. Combination of anticoagulant and antiaggregatory activity in the same molecular entity is presented as a new

ANTITHROMBOTIC COMPOUNDS WITH DUAL FUNCTION

The present invention comprises compounds of the general formula (I) : and pharmaceutically acceptable salts thereof, wherein the substituents have in the description specified meaning. The compounds are used as antithrombotic agents possessing inhibitory