N-(3,4-dichlorophenyl)pyrazine-2-carboxamide

Base Information

Chemical Name:N-(3,4-dichlorophenyl)pyrazine-2-carboxamide
CAS No.:126532-06-7
Molecular Formula:C₁₁H₇Cl₂N₃O
Molecular Weight:268.102
Hs Code.:
DSSTox Substance ID:DTXSID301257562
Nikkaji Number:J3.413.761G
ChEMBL ID:CHEMBL559828

Synonyms:N-(3,4-dichlorophenyl)pyrazine-2-carboxamide;CHEMBL559828;126532-06-7;Cambridge id 5534198;Oprea1_693886;SCHEMBL11903751;DTXSID301257562;BDBM50293733;STK431966;AKOS001311876;N-(3,4-Dichlorophenyl)-2-pyrazinecarboxamide;VU0022481-2;AB00087763-01;EN300-18116085;SR-01000211804;SR-01000211804-1;Z28128464

Suppliers and Price of N-(3,4-dichlorophenyl)pyrazine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3,4-dichlorophenyl)pyrazine-2-carboxamide

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:266.9966172
Heavy Atom Count:17
Complexity:277

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1NC(=O)C2=NC=CN=C2)Cl)Cl

Technology Process of N-(3,4-dichlorophenyl)pyrazine-2-carboxamide

There total 3 articles about N-(3,4-dichlorophenyl)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-97-5
2-pyrazylcarboxylic acid

: 95-76-1
m,p-dichloroaniline

: 126532-06-7
N-(3,4-dichlorophenyl)pyrazine-2-carboxamide

Guidance literature:: 2-pyrazylcarboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃;

m,p-dichloroaniline; In 1,4-dioxane; at 50 ℃;
DOI:10.1021/jm9005065

Reference yield:

: 19847-10-0
pyrazinoyl chloride

: 95-76-1
m,p-dichloroaniline

: 126532-06-7
N-(3,4-dichlorophenyl)pyrazine-2-carboxamide

Guidance literature:: With pyridine; In acetone; at 20 ℃;
DOI:10.3390/molecules15128567

Reference yield:

: 98-97-5
2-pyrazylcarboxylic acid

: 126532-06-7
N-(3,4-dichlorophenyl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 1 h / Reflux

2: pyridine / acetone / 20 °C

With pyridine; thionyl chloride; In acetone; toluene;
DOI:10.3390/molecules15128567