1(RS)-[1-(3,4-dichlorobenzyl)piperidin-4-ylmethyl]-2-methylpropylamine

Base Information

• Chemical Name: 1(RS)-[1-(3,4-dichlorobenzyl)piperidin-4-ylmethyl]-2-methylpropylamine
• CAS No.: 220772-56-5
• Molecular Formula: C₁₇H₂₆Cl₂N₂
• Molecular Weight: 329.313
• Mol file: 220772-56-5.mol

Synonyms:1(RS)-[1-(3,4-dichlorobenzyl)piperidin-4-ylmethyl]-2-methylpropylamine

Chemical Property of 1(RS)-[1-(3,4-dichlorobenzyl)piperidin-4-ylmethyl]-2-methylpropylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1(RS)-[1-(3,4-dichlorobenzyl)piperidin-4-ylmethyl]-2-methylpropylamine

There total 6 articles about 1(RS)-[1-(3,4-dichlorobenzyl)piperidin-4-ylmethyl]-2-methylpropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidin-4-one (41661-47-6) → 1(RS)-[1-(3,4-dichlorobenzyl)piperidin-4-ylmethyl]-2-methylpropylamine (220772-56-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 83 percent / Et₃N / CH₂Cl₂

2.1: 97 percent / NaH / tetrahydrofuran

3.1: 99 percent / H₂ / PtO₂ / ethyl acetate

4.1: iBu₂AlH / toluene / -60 °C

4.2: tetrahydrofuran / 0 °C

5.1: 81 percent / PDC / CH₂Cl₂

6.1: 96 percent / ammonium formate; NaCNBH₃

With dipyridinium dichromate; hydrogen; ammonium formate; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene; 2.1: Horner-Emmons reaction;

DOI:10.1016/S0960-894X(03)00748-0

Reference yield:

3,4-dichlorobenzyl bromide (18880-04-1) → 1(RS)-[1-(3,4-dichlorobenzyl)piperidin-4-ylmethyl]-2-methylpropylamine (220772-56-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 83 percent / Et₃N / CH₂Cl₂

2.1: 97 percent / NaH / tetrahydrofuran

3.1: 99 percent / H₂ / PtO₂ / ethyl acetate

4.1: iBu₂AlH / toluene / -60 °C

4.2: tetrahydrofuran / 0 °C

5.1: 81 percent / PDC / CH₂Cl₂

6.1: 96 percent / ammonium formate; NaCNBH₃

With dipyridinium dichromate; hydrogen; ammonium formate; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene; 2.1: Horner-Emmons reaction;

DOI:10.1016/S0960-894X(03)00748-0

Reference yield:

1-(3,4-dichlorobenzyl)-4-piperidone (220772-52-1) → 1(RS)-[1-(3,4-dichlorobenzyl)piperidin-4-ylmethyl]-2-methylpropylamine (220772-56-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 97 percent / NaH / tetrahydrofuran

2.1: 99 percent / H₂ / PtO₂ / ethyl acetate

3.1: iBu₂AlH / toluene / -60 °C

3.2: tetrahydrofuran / 0 °C

4.1: 81 percent / PDC / CH₂Cl₂

5.1: 96 percent / ammonium formate; NaCNBH₃

With dipyridinium dichromate; hydrogen; ammonium formate; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene; 1.1: Horner-Emmons reaction;

DOI:10.1016/S0960-894X(03)00748-0

upstream raw materials:

piperidin-4-one

3,4-dichlorobenzyl bromide

ethyl [1-(3,4-dichlorobenzyl)piperidin-4-yl]acetate

1-(3,4-dichlorobenzyl)-4-piperidone

Refernces