(S)-2-[2-(4-chlorophenyl)acetamido]-3-(1H-indol-3-yl)propanoic acid

Base Information

• Chemical Name: (S)-2-[2-(4-chlorophenyl)acetamido]-3-(1H-indol-3-yl)propanoic acid
• CAS No.: 39545-23-8
• Molecular Formula: C₁₉H₁₇ClN₂O₃
• Molecular Weight: 356.809
• Mol file: 39545-23-8.mol

Synonyms:(S)-2-[2-(4-chlorophenyl)acetamido]-3-(1H-indol-3-yl)propanoic acid

Chemical Property of (S)-2-[2-(4-chlorophenyl)acetamido]-3-(1H-indol-3-yl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[2-(4-chlorophenyl)acetamido]-3-(1H-indol-3-yl)propanoic acid

There total 4 articles about (S)-2-[2-(4-chlorophenyl)acetamido]-3-(1H-indol-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

→ (S)-2-[2-(4-chlorophenyl)acetamido]-3-(1H-indol-3-yl)propanoic acid (39545-23-8)

Guidance literature:

Reference yield: 90.0%

4-chlorophenacetyl chloride (25026-34-0) + L-Tryptophan (73-22-3,27732-43-0,80206-30-0,27813-82-7) → (S)-2-[2-(4-chlorophenyl)acetamido]-3-(1H-indol-3-yl)propanoic acid (39545-23-8)

Guidance literature:

L-Tryptophan; With sodium hydroxide; In water; at 0 ℃; Cooling with ice;

4-chlorophenacetyl chloride; In water; at 0 ℃; for 0.55h; Cooling with ice;

DOI:10.14233/ajchem.2020.22416

Reference yield:

4-chlorophenylacetic Acid (1878-66-6) → (S)-2-[2-(4-chlorophenyl)acetamido]-3-(1H-indol-3-yl)propanoic acid (39545-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 3 h / -4 - 20 °C / Cooling with ice

2.1: sodium hydroxide / water / 0 °C / Cooling with ice

2.2: 0.55 h / 0 °C / Cooling with ice

With thionyl chloride; sodium hydroxide; In water;

DOI:10.14233/ajchem.2020.22416

upstream raw materials:

4-chlorophenylacetic Acid

4-chlorophenacetyl chloride

L-Tryptophan