N-<2-<2-methoxycarbonylphenoxy>ethyl>-2-<3-hydroxymethylphenyl>acetamide

Base Information

Chemical Name:N-<2-<2-methoxycarbonylphenoxy>ethyl>-2-<3-hydroxymethylphenyl>acetamide
CAS No.:158014-90-5
Molecular Formula:C₁₉H₂₁NO₅
Molecular Weight:343.379
Hs Code.:

Synonyms:N-<2-<2-methoxycarbonylphenoxy>ethyl>-2-<3-hydroxymethylphenyl>acetamide

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Chemical Property of N-<2-<2-methoxycarbonylphenoxy>ethyl>-2-<3-hydroxymethylphenyl>acetamide

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Technology Process of N-<2-<2-methoxycarbonylphenoxy>ethyl>-2-<3-hydroxymethylphenyl>acetamide

There total 6 articles about N-<2-<2-methoxycarbonylphenoxy>ethyl>-2-<3-hydroxymethylphenyl>acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 149492-32-0
3-hydroxymethylphenylacetic acid

: methyl 2-(2-aminoethoxy)benzoate hydrochloride

: 158014-90-5
N-<2-<2-methoxycarbonylphenoxy>ethyl>-2-<3-hydroxymethylphenyl>acetamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; acetonitrile; at 20 ℃; for 24h;

Reference yield:

: 1878-69-9
3-iodophenylacetic acid

: 158014-90-5
N-<2-<2-methoxycarbonylphenoxy>ethyl>-2-<3-hydroxymethylphenyl>acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / Pd(OAc)2, Et₃N / acetonitrile / 10 h / 100 °C

2: 1.) O₃/O₂, 2.) NaBH₄, NaOH / 1.) MeOH, -5 deg C, 2.) MeOH, EtOH, water, RT, 15 h

3: 68 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, triethylamine / acetonitrile; tetrahydrofuran / 24 h / 20 °C

With palladium diacetate; sodium hydroxide; sodium tetrahydroborate; oxygen; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; acetonitrile;

Reference yield:

: 2-(2-aminoethoxy)benzoic acid hydrochloride

: 158014-90-5
N-<2-<2-methoxycarbonylphenoxy>ethyl>-2-<3-hydroxymethylphenyl>acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / SOCl₂ / 10 h / 40 °C

2: 68 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, triethylamine / acetonitrile; tetrahydrofuran / 24 h / 20 °C

With thionyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; acetonitrile;