(S)-2-((2S,3S)-2-{2-[2-((S)-2-{2-[2-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-acetylamino]-acetylamino}-4-methyl-pentanoylamino)-2-methyl-propionylamino]-acetylamino}-3-methyl-pentanoylamino)-4-methyl-pentanoic acid methyl ester

Base Information

• Chemical Name: (S)-2-((2S,3S)-2-{2-[2-((S)-2-{2-[2-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-acetylamino]-acetylamino}-4-methyl-pentanoylamino)-2-methyl-propionylamino]-acetylamino}-3-methyl-pentanoylamino)-4-methyl-pentanoic acid methyl ester
• CAS No.: 176664-80-5
• Molecular Formula: C₄₁H₆₆N₈O₁₁
• Molecular Weight: 847.022

Synonyms:(S)-2-((2S,3S)-2-{2-[2-((S)-2-{2-[2-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-acetylamino]-acetylamino}-4-methyl-pentanoylamino)-2-methyl-propionylamino]-acetylamino}-3-methyl-pentanoylamino)-4-methyl-pentanoic acid methyl ester

Chemical Property of (S)-2-((2S,3S)-2-{2-[2-((S)-2-{2-[2-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-acetylamino]-acetylamino}-4-methyl-pentanoylamino)-2-methyl-propionylamino]-acetylamino}-3-methyl-pentanoylamino)-4-methyl-pentanoic acid methyl ester

Chemical Property:

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Technology Process of (S)-2-((2S,3S)-2-{2-[2-((S)-2-{2-[2-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-acetylamino]-acetylamino}-4-methyl-pentanoylamino)-2-methyl-propionylamino]-acetylamino}-3-methyl-pentanoylamino)-4-methyl-pentanoic acid methyl ester

There total 15 articles about (S)-2-((2S,3S)-2-{2-[2-((S)-2-{2-[2-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-acetylamino]-acetylamino}-4-methyl-pentanoylamino)-2-methyl-propionylamino]-acetylamino}-3-methyl-pentanoylamino)-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Leu-OH (2018-66-8) → (S)-2-((2S,3S)-2-{2-[2-((S)-2-{2-[2-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-acetylamino]-acetylamino}-4-methyl-pentanoylamino)-2-methyl-propionylamino]-acetylamino}-3-methyl-pentanoylamino)-4-methyl-pentanoic acid methyl ester (176664-80-5)

Guidance literature:

Multi-step reaction with 8 steps

1: NMM

2: NMM

3: H₂ / Pd/C

4: NMM

5: H₂ / Pd/C

6: NMM

7: H₂ / Pd/C

8: NMM

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal;

DOI:10.1021/ja954081o

Reference yield:

Z-Aib-OH (15030-72-5) → (S)-2-((2S,3S)-2-{2-[2-((S)-2-{2-[2-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-acetylamino]-acetylamino}-4-methyl-pentanoylamino)-2-methyl-propionylamino]-acetylamino}-3-methyl-pentanoylamino)-4-methyl-pentanoic acid methyl ester (176664-80-5)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂, TEA / ethyl acetate

2: NMM

With 4-methyl-morpholine; thionyl chloride; TEA; In ethyl acetate;

DOI:10.1021/ja954081o

Reference yield:

Z-Gly-L-Ile-L-Leu-OMe (119768-10-4,119784-32-6,119784-35-9,127912-93-0,119768-28-4) → (S)-2-((2S,3S)-2-{2-[2-((S)-2-{2-[2-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-acetylamino]-acetylamino}-4-methyl-pentanoylamino)-2-methyl-propionylamino]-acetylamino}-3-methyl-pentanoylamino)-4-methyl-pentanoic acid methyl ester (176664-80-5)

Guidance literature:

Multi-step reaction with 10 steps

1: H₂ / Pd/C

2: NMM

3: H₂ / Pd/C

4: NMM

5: H₂ / Pd/C

6: NMM

7: H₂ / Pd/C

8: NMM

9: H₂ / Pd/C

10: NMM

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal;

DOI:10.1021/ja954081o

upstream raw materials:

(Z-Aib)2O

H-Gly-Gly-Leu-Aib-Gly-Ile-Leu-OMe

Z-Leu-OH

Z-Aib-OH

Downstream raw materials:

C₄₇H₇₇N₉O₁₂

Z-Gly-L-Leu-Aib-(Gly)2-L-Leu-Aib-Gly-L-Ile-L-Leu-OMe

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