Technology Process of ethyl 2,2-dimethyl-3-(4-toluenesulfonyloxy)butanoate
There total 1 articles about ethyl 2,2-dimethyl-3-(4-toluenesulfonyloxy)butanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 18 h / 130 °C / Inert atmosphere
2: sodium hydroxide / water; ethanol / 18 h / 20 °C / Inert atmosphere
3: dicyclohexyl-carbodiimide / dichloromethane / 20 °C / Inert atmosphere
With
1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; sodium hydroxide;
In
ethanol; dichloromethane; water;
DOI:10.1021/acs.orglett.5b01966
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 96 percent / DBU / 3 h / 140 °C
2.1: 99 percent / NaOH / ethanol / 16 h / 20 °C
3.1: thionyl chloride; DMF / 20 - 80 °C
4.1: 8.1 g / n-BuLi / tetrahydrofuran; hexane / 1 h / -65 °C
5.1: 77 percent / sulfuryl chloride / CHCl3 / Heating
6.1: 48 percent / H2O / 4 h / 145 °C
7.1: 50 percent / DIBALH / toluene / 1 h / -30 °C
8.1: 95 percent / MnO2 / acetone / 1 h / 20 °C
9.1: Cs2CO3 / dimethylformamide / 16 h / 20 °C
9.2: 7 percent / aq. NH4OH / 12 h / 20 °C
With
manganese(IV) oxide; sodium hydroxide; n-butyllithium; thionyl chloride; sulfuryl dichloride; diisobutylaluminium hydride; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide;
In
tetrahydrofuran; ethanol; hexane; chloroform; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jo0012905