(S)-2-benzyl-3,3,3-trifluoro-2-(((R)-2-methoxy-1-phenylethyl)amino)propanoic acid

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Chemical Name:(S)-2-benzyl-3,3,3-trifluoro-2-(((R)-2-methoxy-1-phenylethyl)amino)propanoic acid
CAS No.:1332462-08-4
Molecular Formula:C₁₉H₂₀F₃NO₃
Molecular Weight:367.368
Hs Code.:

Synonyms:(S)-2-benzyl-3,3,3-trifluoro-2-(((R)-2-methoxy-1-phenylethyl)amino)propanoic acid

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Chemical Property of (S)-2-benzyl-3,3,3-trifluoro-2-(((R)-2-methoxy-1-phenylethyl)amino)propanoic acid

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Technology Process of (S)-2-benzyl-3,3,3-trifluoro-2-(((R)-2-methoxy-1-phenylethyl)amino)propanoic acid

There total 2 articles about (S)-2-benzyl-3,3,3-trifluoro-2-(((R)-2-methoxy-1-phenylethyl)amino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1332461-98-9
ethyl (S)-2-benzyl-3,3,3-trifluoro-2-(((R)-2-methoxy-1-phenylethyl)amino)propanoate

: 1332462-08-4
(S)-2-benzyl-3,3,3-trifluoro-2-(((R)-2-methoxy-1-phenylethyl)amino)propanoic acid

Guidance literature:: ethyl (S)-2-benzyl-3,3,3-trifluoro-2-(((R)-2-methoxy-1-phenylethyl)amino)propanoate; With potassium hydroxide; In methanol; water; at 20 ℃; for 36h;

With hydrogenchloride; water; In methanol; pH=1 - 2;
DOI:10.1016/j.tetlet.2011.07.006

Reference yield:

: 1258209-32-3
C₁₄H₁₆F₃NO₃

: 1332462-08-4
(S)-2-benzyl-3,3,3-trifluoro-2-(((R)-2-methoxy-1-phenylethyl)amino)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0 °C / Inert atmosphere

2.1: potassium hydroxide / methanol; water / 36 h / 20 °C

2.2: pH 1 - 2

With potassium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.tetlet.2011.07.006

Reference yield: 85.0%

: 1332462-08-4
(S)-2-benzyl-3,3,3-trifluoro-2-(((R)-2-methoxy-1-phenylethyl)amino)propanoic acid

: 129939-31-7
(S)-2-amino-2-benzyl-3,3,3-trifluoropropanoic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 24h; under 7600.51 Torr;
DOI:10.1016/j.tetlet.2011.07.006