4-[1-(2-chloro-4-fluorophenyl)-3-formyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenyl 3,3,3-trifluoropropane-1-sulfonate

Base Information

Chemical Name:4-[1-(2-chloro-4-fluorophenyl)-3-formyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenyl 3,3,3-trifluoropropane-1-sulfonate
CAS No.:1069136-91-9
Molecular Formula:C₂₈H₂₆ClF₄N₃O₅S
Molecular Weight:628.044
Hs Code.:

4-[1-(2-chloro-4-fluorophenyl)-3-formyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenyl 3,3,3-trifluoropropane-1-sulfonate

Synonyms:4-[1-(2-chloro-4-fluorophenyl)-3-formyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenyl 3,3,3-trifluoropropane-1-sulfonate

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Chemical Property of 4-[1-(2-chloro-4-fluorophenyl)-3-formyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenyl 3,3,3-trifluoropropane-1-sulfonate

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Technology Process of 4-[1-(2-chloro-4-fluorophenyl)-3-formyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenyl 3,3,3-trifluoropropane-1-sulfonate

There total 8 articles about 4-[1-(2-chloro-4-fluorophenyl)-3-formyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenyl 3,3,3-trifluoropropane-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1069136-90-8
ethyl 3-[1-(2-chloro-4-fluorophenyl)-4-oxo-5-piperidin-1-yl-2-(4-{[(3,3,3-trifluoropropyl)sulfonyl]oxy}phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

: 1069136-91-9
4-[1-(2-chloro-4-fluorophenyl)-3-formyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenyl 3,3,3-trifluoropropane-1-sulfonate

Guidance literature:: With sodium periodate; osmium(VIII) oxide; water; In tetrahydrofuran; tert-butyl alcohol;

Reference yield:

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 1069136-91-9
4-[1-(2-chloro-4-fluorophenyl)-3-formyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenyl 3,3,3-trifluoropropane-1-sulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

1.2: 1.75 h / 0 °C

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

3.1: tetrabutyl-ammonium chloride; sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 4.42 h / 80 °C

4.1: boron tribromide / dichloromethane / 1.17 h / 0 °C

5.1: triethylamine / dichloromethane / 0.83 h / 0 °C

6.1: sodium periodate; osmium(VIII) oxide; water / tetrahydrofuran; tert-butyl alcohol

With sodium periodate; N-iodo-succinimide; osmium(VIII) oxide; tetrabutyl-ammonium chloride; water; boron tribromide; sodium hydride; sodium carbonate; triethylamine; palladium diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 932739-14-5
4-(2-chloro-4-fluorophenylamino)-5,6,3',4',5',6'-hexahydro-2'H-[1,1']bipyridinyl-2-one

: 1069136-91-9
4-[1-(2-chloro-4-fluorophenyl)-3-formyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenyl 3,3,3-trifluoropropane-1-sulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

1.2: 1.75 h / 0 °C

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

3.1: tetrabutyl-ammonium chloride; sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 4.42 h / 80 °C

4.1: boron tribromide / dichloromethane / 1.17 h / 0 °C

5.1: triethylamine / dichloromethane / 0.83 h / 0 °C

6.1: sodium periodate; osmium(VIII) oxide; water / tetrahydrofuran; tert-butyl alcohol

With sodium periodate; N-iodo-succinimide; osmium(VIII) oxide; tetrabutyl-ammonium chloride; water; boron tribromide; sodium hydride; sodium carbonate; triethylamine; palladium diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;