ethyl 3-[1-(2-chloro-4-fluorophenyl)-4-oxo-5-piperidin-1-yl-2-(4-{[(3,3,3-trifluoropropyl)sulfonyl]oxy}phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

Base Information

Chemical Name:ethyl 3-[1-(2-chloro-4-fluorophenyl)-4-oxo-5-piperidin-1-yl-2-(4-{[(3,3,3-trifluoropropyl)sulfonyl]oxy}phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate
CAS No.:1069136-90-8
Molecular Formula:C₃₂H₃₂ClF₄N₃O₆S
Molecular Weight:698.135
Hs Code.:

ethyl 3-[1-(2-chloro-4-fluorophenyl)-4-oxo-5-piperidin-1-yl-2-(4-{[(3,3,3-trifluoropropyl)sulfonyl]oxy}phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

Synonyms:ethyl 3-[1-(2-chloro-4-fluorophenyl)-4-oxo-5-piperidin-1-yl-2-(4-{[(3,3,3-trifluoropropyl)sulfonyl]oxy}phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

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Chemical Property of ethyl 3-[1-(2-chloro-4-fluorophenyl)-4-oxo-5-piperidin-1-yl-2-(4-{[(3,3,3-trifluoropropyl)sulfonyl]oxy}phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

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Technology Process of ethyl 3-[1-(2-chloro-4-fluorophenyl)-4-oxo-5-piperidin-1-yl-2-(4-{[(3,3,3-trifluoropropyl)sulfonyl]oxy}phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

There total 8 articles about ethyl 3-[1-(2-chloro-4-fluorophenyl)-4-oxo-5-piperidin-1-yl-2-(4-{[(3,3,3-trifluoropropyl)sulfonyl]oxy}phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 845866-80-0
3,3,3-trifluoropropane-1-sulfonyl chloride

: 1069136-89-5
ethyl 3-[1-(2-chloro-4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

: 1069136-90-8
ethyl 3-[1-(2-chloro-4-fluorophenyl)-4-oxo-5-piperidin-1-yl-2-(4-{[(3,3,3-trifluoropropyl)sulfonyl]oxy}phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.833333h;

Reference yield:

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 1069136-90-8
ethyl 3-[1-(2-chloro-4-fluorophenyl)-4-oxo-5-piperidin-1-yl-2-(4-{[(3,3,3-trifluoropropyl)sulfonyl]oxy}phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

1.2: 1.75 h / 0 °C

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

3.1: tetrabutyl-ammonium chloride; sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 4.42 h / 80 °C

4.1: boron tribromide / dichloromethane / 1.17 h / 0 °C

5.1: triethylamine / dichloromethane / 0.83 h / 0 °C

With N-iodo-succinimide; tetrabutyl-ammonium chloride; boron tribromide; sodium hydride; sodium carbonate; triethylamine; palladium diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 932739-14-5
4-(2-chloro-4-fluorophenylamino)-5,6,3',4',5',6'-hexahydro-2'H-[1,1']bipyridinyl-2-one

: 1069136-90-8
ethyl 3-[1-(2-chloro-4-fluorophenyl)-4-oxo-5-piperidin-1-yl-2-(4-{[(3,3,3-trifluoropropyl)sulfonyl]oxy}phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

1.2: 1.75 h / 0 °C

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

3.1: tetrabutyl-ammonium chloride; sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 4.42 h / 80 °C

4.1: boron tribromide / dichloromethane / 1.17 h / 0 °C

5.1: triethylamine / dichloromethane / 0.83 h / 0 °C

With N-iodo-succinimide; tetrabutyl-ammonium chloride; boron tribromide; sodium hydride; sodium carbonate; triethylamine; palladium diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;