3,4-bis-(benzyloxy)-ω-(benzhydrylamino)acetophenone

Base Information

• Chemical Name: 3,4-bis-(benzyloxy)-ω-(benzhydrylamino)acetophenone
• CAS No.: 100112-45-6
• Molecular Formula: C₃₅H₃₁NO₃
• Molecular Weight: 513.636
• Mol file: 100112-45-6.mol

Synonyms:3,4-bis-(benzyloxy)-ω-(benzhydrylamino)acetophenone

Chemical Property of 3,4-bis-(benzyloxy)-ω-(benzhydrylamino)acetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-bis-(benzyloxy)-ω-(benzhydrylamino)acetophenone

There total 2 articles about 3,4-bis-(benzyloxy)-ω-(benzhydrylamino)acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-bis(benzyloxy)acetophenone (5878-50-2) → 3,4-bis-(benzyloxy)-ω-(benzhydrylamino)acetophenone (100112-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / Br₂ / methanol / 2 h / Heating

2: benzene; ethanol / 0.58 h / 20 - 50 °C

With bromine; In methanol; ethanol; benzene;

DOI:10.1021/jm00155a025

Reference yield:

2-bromo-3',4'-bis(benzyloxy)acetophenone (27628-05-3) + Benzhydrylamine (91-00-9) → 3,4-bis-(benzyloxy)-ω-(benzhydrylamino)acetophenone (100112-45-6)

Guidance literature:

In ethanol; benzene; at 20 - 50 ℃; for 0.583333h;

DOI:10.1021/jm00155a025

Reference yield:

3,4-bis-(benzyloxy)-ω-(benzhydrylamino)acetophenone (100112-45-6) → UK-42620 (54826-84-5)

Guidance literature:

Multi-step reaction with 5 steps

1: LiAlH₄ / diethyl ether / 4 h / Heating

2: 52 percent / Et₃N / CHCl₃ / 4 h / Ambient temperature

3: 58 percent / KOH / ethanol / 30 h / Ambient temperature

4: 35 percent / NaBH₄, BF₃*Et₂O / tetrahydrofuran / 1.5 h / Heating

5: H₂ / 10percent Pd/C / CHCl₃; ethanol

With potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; chloroform;

DOI:10.1021/jm00155a025

upstream raw materials:

2-bromo-3',4'-bis(benzyloxy)acetophenone

Benzhydrylamine

3,4-bis(benzyloxy)acetophenone

Downstream raw materials:

1-<3,4-bis-(benzyloxy)phenyl>-2-(benzhydrylamino)ethanol

UK-42620

4-Benzhydryl-2-(3,4-bis-benzyloxy-phenyl)-morpholine

4-Benzhydryl-6-(3,4-bis-benzyloxy-phenyl)-morpholin-3-one

Refernces