4-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}-4'-(methylthio)biphenyl-3-yl acetate

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Chemical Name:4-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}-4'-(methylthio)biphenyl-3-yl acetate
CAS No.:852204-68-3
Molecular Formula:C₃₉H₄₄FNO₄SSi
Molecular Weight:669.933
Hs Code.:

Synonyms:4-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}-4'-(methylthio)biphenyl-3-yl acetate

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Chemical Property of 4-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}-4'-(methylthio)biphenyl-3-yl acetate

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Technology Process of 4-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}-4'-(methylthio)biphenyl-3-yl acetate

There total 2 articles about 4-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}-4'-(methylthio)biphenyl-3-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 852204-22-9
5-bromo-2-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}phenyl acetate

: 98546-51-1
(4-thiomethoxyphenyl)boronic acid

: 852204-68-3
4-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}-4'-(methylthio)biphenyl-3-yl acetate

Guidance literature:: 5-bromo-2-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}phenyl acetate; (4-thiomethoxyphenyl)boronic acid; With caesium carbonate; bis(1-adamantylamine)palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 4h;

With dmap; acetic anhydride; In 1,4-dioxane; for 0.25h;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield: 52.0%

: 852204-22-9
5-bromo-2-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}phenyl acetate

: 128312-11-8
3-methylthiophenylboronic acid

: 852204-68-3
4-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}-4'-(methylthio)biphenyl-3-yl acetate

Guidance literature:: With caesium carbonate; bis(1-adamantylamine)palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 4h;

Reference yield:

: 852204-68-3
4-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}-4'-(methylthio)biphenyl-3-yl acetate

: C₃₁H₂₈FNO₅S

Guidance literature:: 4-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}-4'-(methylthio)biphenyl-3-yl acetate; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃;

With trifluoroacetic anhydride; In dichloromethane; at 20 ℃; for 8.5h;

With methanol; hydrogen fluoride; water; triethylamine; more than 3 stages;