N-(5-allyloxy-pyrazin-2-yl)-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

Base Information

Chemical Name:N-(5-allyloxy-pyrazin-2-yl)-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide
CAS No.:710322-75-1
Molecular Formula:C₂₂H₂₆ClN₃O₄S
Molecular Weight:463.985
Hs Code.:

Synonyms:N-(5-allyloxy-pyrazin-2-yl)-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-allyloxy-pyrazin-2-yl)-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

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Technology Process of N-(5-allyloxy-pyrazin-2-yl)-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

There total 4 articles about N-(5-allyloxy-pyrazin-2-yl)-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 710322-74-0
5-allyloxy-pyrazin-2-ylamine

: (R)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionyl chloride

: 710322-75-1
N-(5-allyloxy-pyrazin-2-yl)-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

Guidance literature:: With pyridine; In dichloromethane; at 5 - 25 ℃; for 16h;

Reference yield: 80.0%

: 300356-14-3
(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid

: 710322-74-0
5-allyloxy-pyrazin-2-ylamine

: 710322-75-1
N-(5-allyloxy-pyrazin-2-yl)-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

Guidance literature:: (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 25 ℃; for 2.25h; Inert atmosphere;

5-allyloxy-pyrazin-2-ylamine; With pyridine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 25 ℃; Inert atmosphere;
DOI:10.1021/ml400027y

Reference yield:

: 710322-72-8
5-allyloxy-pyrazine-2-carboxylic acid potassium salt

: 710322-75-1
N-(5-allyloxy-pyrazin-2-yl)-2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 18 h / 25 °C / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

3.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2.25 h / 0 - 25 °C / Inert atmosphere

3.2: 0 - 25 °C / Inert atmosphere

With oxalyl dichloride; diphenyl phosphoryl azide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml400027y