2-<2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>ethyl>-5-benzofurancarbonitrile

Base Information

Chemical Name:2-<2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>ethyl>-5-benzofurancarbonitrile
CAS No.:150613-90-4
Molecular Formula:C₂₆H₂₈N₂O₄
Molecular Weight:432.519
Hs Code.:

Synonyms:2-<2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>ethyl>-5-benzofurancarbonitrile

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Chemical Property of 2-<2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>ethyl>-5-benzofurancarbonitrile

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Technology Process of 2-<2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>ethyl>-5-benzofurancarbonitrile

There total 5 articles about 2-<2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>ethyl>-5-benzofurancarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.8%

: (E)/(Z)-2-<2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>vinyl>-5-benzofurancarbonitrile

: 150613-90-4
2-<2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>ethyl>-5-benzofurancarbonitrile

Guidance literature:: With PdP*H₂O*BaSO₄; hydrogen; In tetrahydrofuran; ethanol; for 6h; under 760 Torr; Ambient temperature;
DOI:10.1021/jm00034a018

Reference yield:

: 109431-87-0,83220-73-9
(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

: 150613-90-4
2-<2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>ethyl>-5-benzofurancarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 99.7 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 0.75 h / Ambient temperature

2: 1.90 g / DBU / tetrahydrofuran; ethanol / 1 h / Ambient temperature

3: 86.8 percent / PdP*H₂O*BaSO₄, H₂ / tetrahydrofuran; ethanol / 6 h / 760 Torr / Ambient temperature

With PdP*H₂O*BaSO₄; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00034a018

Reference yield:

: 84102-80-7
<(5-Cyan-1-benzofuran-2-yl)methyl>triphenylphosphoniumchlorid

: 150613-90-4
2-<2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>ethyl>-5-benzofurancarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 1.90 g / DBU / tetrahydrofuran; ethanol / 1 h / Ambient temperature

2: 86.8 percent / PdP*H₂O*BaSO₄, H₂ / tetrahydrofuran; ethanol / 6 h / 760 Torr / Ambient temperature

With PdP*H₂O*BaSO₄; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00034a018