(S)-4-((2R,3S,4S)-3-(benzyloxy)-5-(methoxymethoxy)-4-methylpentan-2-yl)-2,2-dimethyl-1,3-dioxane

Base Information

Chemical Name:(S)-4-((2R,3S,4S)-3-(benzyloxy)-5-(methoxymethoxy)-4-methylpentan-2-yl)-2,2-dimethyl-1,3-dioxane
CAS No.:1360170-20-2
Molecular Formula:C₂₁H₃₄O₅
Molecular Weight:366.498
Hs Code.:

Synonyms:(S)-4-((2R,3S,4S)-3-(benzyloxy)-5-(methoxymethoxy)-4-methylpentan-2-yl)-2,2-dimethyl-1,3-dioxane

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Chemical Property of (S)-4-((2R,3S,4S)-3-(benzyloxy)-5-(methoxymethoxy)-4-methylpentan-2-yl)-2,2-dimethyl-1,3-dioxane

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Technology Process of (S)-4-((2R,3S,4S)-3-(benzyloxy)-5-(methoxymethoxy)-4-methylpentan-2-yl)-2,2-dimethyl-1,3-dioxane

There total 3 articles about (S)-4-((2R,3S,4S)-3-(benzyloxy)-5-(methoxymethoxy)-4-methylpentan-2-yl)-2,2-dimethyl-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (2S,3S,4R)-3-(benzyloxy)-4-((S)-2,2-dimethyl-1,3-dioxan-4-yl)-2-methylpentan-1-ol

: 107-30-2
chloromethyl methyl ether

: 1360170-20-2
(S)-4-((2R,3S,4S)-3-(benzyloxy)-5-(methoxymethoxy)-4-methylpentan-2-yl)-2,2-dimethyl-1,3-dioxane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.11.013

Reference yield:

: 171231-75-7
endo-3-benzyloxy-endo,endo-2,4-dimethyl-6,9-dioxabicyclo[3.2.1]non-7-one

: 1360170-20-2
(S)-4-((2R,3S,4S)-3-(benzyloxy)-5-(methoxymethoxy)-4-methylpentan-2-yl)-2,2-dimethyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere; Reflux

1.2: 0 °C

2.1: toluene-4-sulfonic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2011.11.013

Reference yield:

: 359868-22-7
(3S,4R,5S,6S)-5-(benzyloxy)-4,6-dimethylheptane-1,3,7-triol

: 1360170-20-2
(S)-4-((2R,3S,4S)-3-(benzyloxy)-5-(methoxymethoxy)-4-methylpentan-2-yl)-2,2-dimethyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.tetasy.2011.11.013