5-fluoro-N₂-(4-isopropyl-3-(1H-tetrazol-1-yl)phenyl)-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: 5-fluoro-N₂-(4-isopropyl-3-(1H-tetrazol-1-yl)phenyl)-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine
• CAS No.: 1356493-40-7
• Molecular Formula: C₂₃H₃₂FN₉
• Molecular Weight: 453.566

Synonyms:5-fluoro-N₂-(4-isopropyl-3-(1H-tetrazol-1-yl)phenyl)-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine

Chemical Property of 5-fluoro-N₂-(4-isopropyl-3-(1H-tetrazol-1-yl)phenyl)-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of 5-fluoro-N₂-(4-isopropyl-3-(1H-tetrazol-1-yl)phenyl)-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine

There total 5 articles about 5-fluoro-N₂-(4-isopropyl-3-(1H-tetrazol-1-yl)phenyl)-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-chloro-5-fluoro-N4-(2,2,6,6-tetramethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride + 4-isopropyl-3-(1H-tetrazol-1-yl)benzenamine (1356493-66-7) → 5-fluoro-N2-(4-isopropyl-3-(1H-tetrazol-1-yl)phenyl)-N4-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine (1356493-40-7)

Guidance literature:

2-chloro-5-fluoro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride; 4-isopropyl-3-(1H-tetrazol-1-yl)benzenamine; With toluene-4-sulfonic acid; In isopropyl alcohol; at 100 ℃; for 3h;

With ammonia; In methanol; isopropyl alcohol; at 20 ℃;

Reference yield:

2-isopropylaniline (643-28-7) → 5-fluoro-N2-(4-isopropyl-3-(1H-tetrazol-1-yl)phenyl)-N4-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine (1356493-40-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: nitric acid; sulfuric acid / 0 °C

2.1: acetic acid / 0.17 h / 20 °C

2.2: 1 h / 120 °C

2.3: 0 °C

3.1: ammonium chloride / iron / ethanol; water / 2 h / Reflux

4.1: toluene-4-sulfonic acid / isopropyl alcohol / 3 h / 100 °C

4.2: 20 °C

With sulfuric acid; nitric acid; ammonium chloride; toluene-4-sulfonic acid; acetic acid; iron; In ethanol; water; isopropyl alcohol;

Reference yield:

2-isopropyl-5-nitroaniline (132475-93-5) → 5-fluoro-N2-(4-isopropyl-3-(1H-tetrazol-1-yl)phenyl)-N4-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine (1356493-40-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid / 0.17 h / 20 °C

1.2: 1 h / 120 °C

1.3: 0 °C

2.1: ammonium chloride / iron / ethanol; water / 2 h / Reflux

3.1: toluene-4-sulfonic acid / isopropyl alcohol / 3 h / 100 °C

3.2: 20 °C

With ammonium chloride; toluene-4-sulfonic acid; acetic acid; iron; In ethanol; water; isopropyl alcohol;

upstream raw materials:

4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE

2-isopropylaniline

2-isopropyl-5-nitroaniline

4-isopropyl-3-(1H-tetrazol-1-yl)benzenamine

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