Technology Process of 5-fluoro-N2-(4-isopropyl-3-(1H-tetrazol-1-yl)phenyl)-N4-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine
There total 5 articles about 5-fluoro-N2-(4-isopropyl-3-(1H-tetrazol-1-yl)phenyl)-N4-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-chloro-5-fluoro-N4-(2,2,6,6-tetramethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride; 4-isopropyl-3-(1H-tetrazol-1-yl)benzenamine;
With
toluene-4-sulfonic acid;
In
isopropyl alcohol;
at 100 ℃;
for 3h;
With
ammonia;
In
methanol; isopropyl alcohol;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: nitric acid; sulfuric acid / 0 °C
2.1: acetic acid / 0.17 h / 20 °C
2.2: 1 h / 120 °C
2.3: 0 °C
3.1: ammonium chloride / iron / ethanol; water / 2 h / Reflux
4.1: toluene-4-sulfonic acid / isopropyl alcohol / 3 h / 100 °C
4.2: 20 °C
With
sulfuric acid; nitric acid; ammonium chloride; toluene-4-sulfonic acid; acetic acid;
iron;
In
ethanol; water; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetic acid / 0.17 h / 20 °C
1.2: 1 h / 120 °C
1.3: 0 °C
2.1: ammonium chloride / iron / ethanol; water / 2 h / Reflux
3.1: toluene-4-sulfonic acid / isopropyl alcohol / 3 h / 100 °C
3.2: 20 °C
With
ammonium chloride; toluene-4-sulfonic acid; acetic acid;
iron;
In
ethanol; water; isopropyl alcohol;
